Modeling Long-Term Facilitation of Respiration During Interval Exercise in Humans

Long-term facilitation (LTF) of respiration has been mainly initiated by intermittent hypoxia and resultant chemoreceptor stimulation in humans. Comparable levels of chemoreceptor stimulation can occur in combined exercise and carbon dioxide (CO 2 ) inhalation and lead to LTF. This possibility was s...

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Veröffentlicht in:	Annals of biomedical engineering 2024-02, Vol.52 (2), p.250-258
Hauptverfasser:	Yamashiro, Stanley M., Kato, Takahide, Matsumoto, Takaaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Biochemistry Biological and Medical Physics Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Biophysics Carbon Dioxide Classical Mechanics Exercise - physiology Humans Hypoxia Inhalation Lung Mathematical models Original Original Article Oxygen consumption Oxygen uptake Recovery Respiration Sensitivity Stimulation Ventilation
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Zusammenfassung:	Long-term facilitation (LTF) of respiration has been mainly initiated by intermittent hypoxia and resultant chemoreceptor stimulation in humans. Comparable levels of chemoreceptor stimulation can occur in combined exercise and carbon dioxide (CO 2 ) inhalation and lead to LTF. This possibility was supported by data collected during combined interval exercise and 3% inhaled CO 2 in seven normal subjects. These data were further analyzed based on the dynamics involved using mathematical models in this study. Previously estimated peripheral chemoreceptor sensitivity during light exercise (40 W) with air or 3% inhaled CO 2 approximately doubled resting sensitivity. Ventilation after a delay increased by 17.0 ± 2.48 L/min ( p
ISSN:	0090-6964 1573-9686 1573-9686
DOI:	10.1007/s10439-023-03366-z