Molecular analysis of archival diagnostic prostate cancer biopsies identifies genomic similarities in cases with progression post‐radiotherapy, and those with de novo metastatic disease

Background It is important to identify molecular features that improve prostate cancer (PCa) risk stratification before radical treatment with curative intent. Molecular analysis of historical diagnostic formalin‐fixed paraffin‐embedded (FFPE) prostate biopsies from cohorts with post‐radiotherapy (R...

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Veröffentlicht in:	The Prostate 2024-07, Vol.84 (10), p.977-990
Hauptverfasser:	Charlton, Philip Vincent, O'Reilly, Dawn, Philippou, Yiannis, Rao, Srinivasa Rao, Lamb, Alastair David Gordon, Mills, Ian Geoffrey, Higgins, Geoff Stuart, Hamdy, Freddie Charles, Verrill, Clare, Buffa, Francesca Meteora, Bryant, Richard John
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Biopsy Cohort Studies diagnostic biopsies Disease Progression DNA probes Genomics Humans Male Malignancy Metastases Metastasis Middle Aged molecular analysis Neoplasm Metastasis Original Patients Principal components analysis Prostate - pathology Prostate cancer Prostatic Neoplasms - genetics Prostatic Neoplasms - pathology Prostatic Neoplasms - radiotherapy Radiation therapy radiotherapy Sequence analysis
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