p53 protein expression patterns associated with TP53 mutations in breast carcinoma

Purpose The importance of a TP53 mutation has been demonstrated in several tumor types, including breast cancer (BC). However, the accuracy of p53 protein expression as a predictor of gene mutation has not been well studied in BC. Therefore, we evaluated p53 protein expression associated with TP53 m...

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Veröffentlicht in:	Breast cancer research and treatment 2024-08, Vol.207 (1), p.213-222
Hauptverfasser:	Anderson, Sarah A., Bartow, Brooke B., Harada, Shuko, Siegal, Gene P., Wei, Shi, Dal Zotto, Valeria L., Huang, Xiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Breast cancer Breast carcinoma Breast Neoplasms - genetics Breast Neoplasms - metabolism Breast Neoplasms - pathology Female Frameshift mutation High-Throughput Nucleotide Sequencing Humans Immunohistochemistry Medicine Medicine & Public Health Middle Aged Missense mutation Mutation Next-generation sequencing Nonsense mutation Oncology p53 Protein Phenotypes Point mutation Protein expression Proteins Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Tumors
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