Are children with IgA nephropathy different from adult patients?

Background Previously, several studies have indicated that pediatric IgA nephropathy (IgAN) might be different from adult IgAN, and treatment strategies might be also different between pediatric IgAN and adult IgAN. Methods We analyzed two prospective cohorts established by pediatric and adult nephr...

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Veröffentlicht in:	Pediatric nephrology (Berlin, West) West), 2024-08, Vol.39 (8), p.2403-2412
Hauptverfasser:	Su, Baige, Jiang, Yuanyuan, Li, Zhihui, Zhou, Jianhua, Rong, Liping, Feng, Shipin, Zhong, Fazhan, Sun, Shuzhen, Zhang, Dongfeng, Xia, Zhengkun, Feng, Chunyue, Huang, Wenyan, Li, Xiaoyan, Chen, Chaoying, Hao, Zhihong, Wang, Mo, Qin, Li, Chen, Minguang, Li, Yuanyuan, Ding, Juanjuan, Bao, Ying, Liu, Xiaorong, Deng, Fang, Cheng, Xueqin, Zhang, Li, Zhang, Xuan, Yang, Huandan, Peng, Xiaojie, Sun, Qianliang, Deng, Linxia, Jiang, Xiaoyun, Xie, Min, Gao, Yan, Yu, Lichun, Liu, Ling, Gao, Chunlin, Mao, Jianhua, Zheng, Weihua, Dang, Xiqiang, Xia, Hua, Wang, Yujie, Zhong, Xuhui, Ding, Jie, Lv, Jicheng, Zhang, Hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Adults Age Factors Child Children Disease Progression Epidermal growth factor receptors Female Glomerular Filtration Rate Glomerulonephritis, IGA - complications Glomerulonephritis, IGA - diagnosis Glomerulonephritis, IGA - drug therapy Glomerulonephritis, IGA - pathology Glomerulonephritis, IGA - physiopathology Glomerulonephritis, IGA - therapy Glucocorticoids - therapeutic use Hematuria Hematuria - diagnosis Hematuria - etiology Humans Hypertension Hypertension - diagnosis Hypertension - drug therapy Hypertension - epidemiology IgA nephropathy Immunoglobulin A Kidney - pathology Kidney - physiopathology Male Medicine Medicine & Public Health Middle Aged Nephrology Original Original Article Patients Pediatrics Prognosis Prospective Studies Proteinuria Proteinuria - diagnosis Proteinuria - etiology Remission Steroid hormones Urology Young Adult
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Zusammenfassung:	Background Previously, several studies have indicated that pediatric IgA nephropathy (IgAN) might be different from adult IgAN, and treatment strategies might be also different between pediatric IgAN and adult IgAN. Methods We analyzed two prospective cohorts established by pediatric and adult nephrologists, respectively. A comprehensive analysis was performed investigating the difference in clinical and pathological characteristics, treatment, and prognosis between children and adults with IgAN. Results A total of 1015 children and 1911 adults with IgAN were eligible for analysis. More frequent gross hematuria (88% vs. 20%, p
ISSN:	0931-041X 1432-198X 1432-198X
DOI:	10.1007/s00467-024-06361-1