Overlapping and unique brain responses to cognitive and response inhibition

•Unclear if different aspects of inhibition engage similar brain regions.•Examined brain response to cognitive and response inhibition within a single task.•Cognitive and response inhibition recruited common, overlapping brain regions.•Unique brain regions were also engaged for cognitive and response inhibition. Although cognitive inhibition and response inhibition fall under the umbrella term of inhibition, the question remains whether the two aspects of inhibition engage shared or distinct brain regions. The current study is one of the first to examine the neural underpinnings of cognitive inhibition (e.g. the Stroop incongruency effect) and response inhibition (e.g. “no-go” response) within a single task. Adult participants (n = 77) completed an adapted version of the Simon Task in a 3T MRI scanner. The results demonstrated that cognitive and response inhibition recruited a group of overlapping brain regions (inferior frontal cortex, inferior temporal lobe, precentral cortex, parietal cortex). However, a direct comparison of cognitive and response inhibition revealed that the two aspects of inhibition also engaged distinct, task-specific brain regions (voxel-wise FWE corrected p