Understanding the Role of Endothelial Cells in Glioblastoma: Mechanisms and Novel Treatments

Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays a critical role in glioblastoma growth and progression, facilitating angiogenesis, cellular communication, and tumorigenesis. In this review, we present an up-to-date and comprehe...

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Veröffentlicht in:	International journal of molecular sciences 2024-06, Vol.25 (11), p.6118
Hauptverfasser:	Hovis, Gabrielle, Chandra, Neha, Kejriwal, Nidhi, Hsieh, Kaleb Jia-Yi, Chu, Alison, Yang, Isaac, Wadehra, Madhuri
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals Biomarkers, Tumor - metabolism Blood vessels Brain cancer Brain Neoplasms - metabolism Brain Neoplasms - pathology Brain Neoplasms - therapy Brain research Brain tumors Development and progression Endothelial Cells - metabolism Endothelial Cells - pathology Endothelium Gene amplification Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma - therapy Glioblastoma multiforme Glioma Homeostasis Humans Hypoxia Neovascularization, Pathologic Nervous system Neurogenesis Neurons Permeability Review Smooth muscle Tumors Vascular endothelial growth factor
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Zusammenfassung:	Glioblastoma is a highly aggressive neoplasm and the most common primary malignant brain tumor. Endothelial tissue plays a critical role in glioblastoma growth and progression, facilitating angiogenesis, cellular communication, and tumorigenesis. In this review, we present an up-to-date and comprehensive summary of the role of endothelial cells in glioblastomas, along with an overview of recent developments in glioblastoma therapies and tumor endothelial marker identification.
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms25116118