CRASH trial is based on problematic meta-analysis

Ethics committees considering the safety of high dose steroid treatment in head injury need to consider the significant risks of these doses and weigh them against the vanishingly small benefits that may accrue.

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Bibliographische Detailangaben
Veröffentlicht in:	BMJ 1999-08, Vol.319 (7209), p.578-578
Hauptverfasser:	Gregson, B, Todd, N V, Crawford, D, Gerbe, C J, Fulton, B, Taccon, L, Crawford, P J, Sengupta, R P
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Inflammatory Agents - administration & dosage Confidence intervals Craniocerebral Trauma - drug therapy Experimentation Head injuries Humans Letters Medical specialists Meta-analysis Meta-Analysis as Topic Odds Ratio Patients Prednisolone - administration & dosage Randomized Controlled Trials as Topic - standards Steroids
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Beschreibung
Zusammenfassung:	Ethics committees considering the safety of high dose steroid treatment in head injury need to consider the significant risks of these doses and weigh them against the vanishingly small benefits that may accrue.
ISSN:	0959-8138 1468-5833 1756-1833
DOI:	10.1136/bmj.319.7209.578