Midkine and its clinical significance in endometrial carcinoma

Midkine (MK) is a secreted heparin‐binding growth factor. Several types of human cancer have increased MK expression with elevated serum levels. The purpose of this study was to determine whether MK was expressed in endometrial carcinoma and to evaluate the clinicopathological significance of serum...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer science 2008-06, Vol.99 (6), p.1125-1130
Hauptverfasser:	Tanabe, Kojiro, Matsumoto, Mitsuyo, Ikematsu, Shinya, Nagase, Satoru, Hatakeyama, Atsushi, Takano, Tadao, Niikura, Hitoshi, Ito, Kiyoshi, Kadomatsu, Kenji, Hayashi, Shin‐ichi, Yaegashi, Nobuo
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Biomarkers, Tumor - blood Carcinoma, Endometrioid - metabolism Carcinoma, Endometrioid - secondary Endometrial Neoplasms - metabolism Endometrial Neoplasms - pathology Enzyme-Linked Immunosorbent Assay Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Lymphatic Metastasis Medical sciences Middle Aged Midkine Neoplasm Invasiveness Neoplasm Staging Nerve Growth Factors - metabolism Original /Report Prognosis Tumors
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Midkine (MK) is a secreted heparin‐binding growth factor. Several types of human cancer have increased MK expression with elevated serum levels. The purpose of this study was to determine whether MK was expressed in endometrial carcinoma and to evaluate the clinicopathological significance of serum MK in patients with endometrial carcinoma. Immunohistochemical expression of MK was evaluated in 85 endometrial carcinoma samples and 33 controls. MK expression was significantly higher in the carcinomas than in normal endometrium (P
ISSN:	1347-9032 1349-7006 1349-7006
DOI:	10.1111/j.1349-7006.2008.00796.x