Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1–cyclin‐dependent kinase 4–p21 pathway
We have investigated the expression and role of the 58‐kDa microspherule protein (MSP58) in colorectal carcinoma (CRC). By immuhistochemistry and immunofluorescence, we observed MSP58 in the nucleus and cytoplasm of CRC cells, and found MSP58 to be present in CRC specimens more often than in adjacen...
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| Veröffentlicht in: | Cancer science 2009-09, Vol.100 (9), p.1585-1590 |
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| creator | Shi, Hai Chen, Sunxiao Jin, Haifeng Xu, Chunsheng Dong, Guanglong Zhao, Qingchuan Wang, Weizhong Zhang, Hongwei Lin, Wei Zhang, Jing Davidovic, Laetitia Yao, Libo Fan, Daiming |
| description | We have investigated the expression and role of the 58‐kDa microspherule protein (MSP58) in colorectal carcinoma (CRC). By immuhistochemistry and immunofluorescence, we observed MSP58 in the nucleus and cytoplasm of CRC cells, and found MSP58 to be present in CRC specimens more often than in adjacent non‐tumor tissues (92.5 vs 36.3%, P |
| doi_str_mv | 10.1111/j.1349-7006.2009.01223.x |
| format | Article |
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By immuhistochemistry and immunofluorescence, we observed MSP58 in the nucleus and cytoplasm of CRC cells, and found MSP58 to be present in CRC specimens more often than in adjacent non‐tumor tissues (92.5 vs 36.3%, P < 0.01). The average staining score in adjacent non‐tumor tissues was significantly lower than in CRC tissues (2.05 ± 1.13 vs 5.23 ± 1.38, P < 0.01). Moreover, MSP58 mRNA and protein appeared to be upregulated in six fresh CRC samples compared to their adjacent non‐cancerous tissues. MSP58 expression was also detected in the human CRC‐derived cell lines LoVo, CoLo205, HCT116, HT‐29, SW620, and SW480. Downregulation of MSP58 inhibited in vitro growth and attenuated tumor growth in animal models by induction of cell cycle arrest, and was associated with reduced levels of cyclin D1, cyclin‐dependent kinase 4, phosphorylation‐Rb (p‐Rb), p21, and Retino blastoma (Rb) proteins. These results indicated that MSP58 might play an important role in the carcinogenesis of CRC via regulation of the cyclin D1–cyclin‐dependent kinase 4–p21 pathway. (Cancer Sci 2009; 100: 1585–1590)</description><identifier>ISSN: 1347-9032</identifier><identifier>ISSN: 1349-7006</identifier><identifier>EISSN: 1349-7006</identifier><identifier>DOI: 10.1111/j.1349-7006.2009.01223.x</identifier><identifier>PMID: 19549253</identifier><language>eng</language><publisher>Melbourne, Australia: Blackwell Publishing Asia</publisher><subject>Biological and medical sciences ; Blotting, Western ; Cell Cycle ; Cell Proliferation ; Colony-Forming Units Assay ; Colorectal Neoplasms - genetics ; Colorectal Neoplasms - metabolism ; Colorectal Neoplasms - pathology ; Cyclin D1 - metabolism ; Cyclin-Dependent Kinase 4 - metabolism ; Cyclin-Dependent Kinase Inhibitor p21 - metabolism ; Down-Regulation - physiology ; Enzyme-Linked Immunosorbent Assay ; Flow Cytometry ; Fluorescent Antibody Technique ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Immunoenzyme Techniques ; Medical sciences ; Nuclear Proteins - genetics ; Nuclear Proteins - metabolism ; Original ; Phosphorylation ; Reverse Transcriptase Polymerase Chain Reaction ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; RNA-Binding Proteins - genetics ; RNA-Binding Proteins - metabolism ; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus ; Subcellular Fractions ; Tumor Cells, Cultured ; Tumors</subject><ispartof>Cancer science, 2009-09, Vol.100 (9), p.1585-1590</ispartof><rights>2009 Japanese Cancer Association</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5633-89835cfa11dddeb80dd80e29fa9d29895efcbbe745185db05f72dac6491fe26d3</citedby><cites>FETCH-LOGICAL-c5633-89835cfa11dddeb80dd80e29fa9d29895efcbbe745185db05f72dac6491fe26d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11158322/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11158322/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,1411,11543,27903,27904,45553,45554,46030,46454,53769,53771</link.rule.ids><linktorsrc>$$Uhttps://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1349-7006.2009.01223.x$$EView_record_in_Wiley-Blackwell$$FView_record_in_$$GWiley-Blackwell</linktorsrc><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21876653$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19549253$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shi, Hai</creatorcontrib><creatorcontrib>Chen, Sunxiao</creatorcontrib><creatorcontrib>Jin, Haifeng</creatorcontrib><creatorcontrib>Xu, Chunsheng</creatorcontrib><creatorcontrib>Dong, Guanglong</creatorcontrib><creatorcontrib>Zhao, Qingchuan</creatorcontrib><creatorcontrib>Wang, Weizhong</creatorcontrib><creatorcontrib>Zhang, Hongwei</creatorcontrib><creatorcontrib>Lin, Wei</creatorcontrib><creatorcontrib>Zhang, Jing</creatorcontrib><creatorcontrib>Davidovic, Laetitia</creatorcontrib><creatorcontrib>Yao, Libo</creatorcontrib><creatorcontrib>Fan, Daiming</creatorcontrib><title>Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1–cyclin‐dependent kinase 4–p21 pathway</title><title>Cancer science</title><addtitle>Cancer Sci</addtitle><description>We have investigated the expression and role of the 58‐kDa microspherule protein (MSP58) in colorectal carcinoma (CRC). By immuhistochemistry and immunofluorescence, we observed MSP58 in the nucleus and cytoplasm of CRC cells, and found MSP58 to be present in CRC specimens more often than in adjacent non‐tumor tissues (92.5 vs 36.3%, P < 0.01). The average staining score in adjacent non‐tumor tissues was significantly lower than in CRC tissues (2.05 ± 1.13 vs 5.23 ± 1.38, P < 0.01). Moreover, MSP58 mRNA and protein appeared to be upregulated in six fresh CRC samples compared to their adjacent non‐cancerous tissues. MSP58 expression was also detected in the human CRC‐derived cell lines LoVo, CoLo205, HCT116, HT‐29, SW620, and SW480. Downregulation of MSP58 inhibited in vitro growth and attenuated tumor growth in animal models by induction of cell cycle arrest, and was associated with reduced levels of cyclin D1, cyclin‐dependent kinase 4, phosphorylation‐Rb (p‐Rb), p21, and Retino blastoma (Rb) proteins. These results indicated that MSP58 might play an important role in the carcinogenesis of CRC via regulation of the cyclin D1–cyclin‐dependent kinase 4–p21 pathway. (Cancer Sci 2009; 100: 1585–1590)</description><subject>Biological and medical sciences</subject><subject>Blotting, Western</subject><subject>Cell Cycle</subject><subject>Cell Proliferation</subject><subject>Colony-Forming Units Assay</subject><subject>Colorectal Neoplasms - genetics</subject><subject>Colorectal Neoplasms - metabolism</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Cyclin D1 - metabolism</subject><subject>Cyclin-Dependent Kinase 4 - metabolism</subject><subject>Cyclin-Dependent Kinase Inhibitor p21 - metabolism</subject><subject>Down-Regulation - physiology</subject><subject>Enzyme-Linked Immunosorbent Assay</subject><subject>Flow Cytometry</subject><subject>Fluorescent Antibody Technique</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Immunoenzyme Techniques</subject><subject>Medical sciences</subject><subject>Nuclear Proteins - genetics</subject><subject>Nuclear Proteins - metabolism</subject><subject>Original</subject><subject>Phosphorylation</subject><subject>Reverse Transcriptase Polymerase Chain Reaction</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>RNA-Binding Proteins - genetics</subject><subject>RNA-Binding Proteins - metabolism</subject><subject>Stomach. Duodenum. Small intestine. Colon. Rectum. Anus</subject><subject>Subcellular Fractions</subject><subject>Tumor Cells, Cultured</subject><subject>Tumors</subject><issn>1347-9032</issn><issn>1349-7006</issn><issn>1349-7006</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc1u1DAUhSMEomXgFZA3sEvwT5zYC4SqafmRikAqrC3HdiYePHawM53Oro-ABE_YJyGZGQ10Bd74Sue718f3ZBlAsEDjebUsECl5XkNYFRhCXkCEMSluHmSnR-Hhrq5zDgk-yZ6ktISQVCUvH2cniNOSY0pOs1_nYeOjWaydHGzwILTg49VnyoD1nW3skMAihs3QTUK3XkkPVHAhGjVIB5T0ykSgjHMJXFsJ7g8aOgPUVjnrwTm6u_25r-9uf2jTG6-NH8A362UyoBzVHiPQy6HbyO3T7FErXTLPDvcs-_r24sv8fX756d2H-dllrmhFSM44I1S1EiGttWkY1JpBg3krucaccWpa1TSmLiliVDeQtjXWUo07QK3BlSaz7M1-br9uVkar0VGUTvTRrmTciiCtuK9424lFuBZjBpSRceWz7OVhQgzf1yYNYmXTtA_pTVgnUdWUc1LBf4IYVpyzko4g24MqhpSiaY92EJzeRWIppozFlLGYwhe78MXN2Pr87-_8aTykPQIvDoBMSro2jvnZdOQwYnVV7bjXe25jndn-twExP7uaKvIbi6nQ9A</recordid><startdate>200909</startdate><enddate>200909</enddate><creator>Shi, Hai</creator><creator>Chen, Sunxiao</creator><creator>Jin, Haifeng</creator><creator>Xu, Chunsheng</creator><creator>Dong, Guanglong</creator><creator>Zhao, Qingchuan</creator><creator>Wang, Weizhong</creator><creator>Zhang, Hongwei</creator><creator>Lin, Wei</creator><creator>Zhang, Jing</creator><creator>Davidovic, Laetitia</creator><creator>Yao, Libo</creator><creator>Fan, Daiming</creator><general>Blackwell Publishing Asia</general><general>Blackwell</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TO</scope><scope>H94</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>200909</creationdate><title>Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1–cyclin‐dependent kinase 4–p21 pathway</title><author>Shi, Hai ; Chen, Sunxiao ; Jin, Haifeng ; Xu, Chunsheng ; Dong, Guanglong ; Zhao, Qingchuan ; Wang, Weizhong ; Zhang, Hongwei ; Lin, Wei ; Zhang, Jing ; Davidovic, Laetitia ; Yao, Libo ; Fan, Daiming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5633-89835cfa11dddeb80dd80e29fa9d29895efcbbe745185db05f72dac6491fe26d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Biological and medical sciences</topic><topic>Blotting, Western</topic><topic>Cell Cycle</topic><topic>Cell Proliferation</topic><topic>Colony-Forming Units Assay</topic><topic>Colorectal Neoplasms - genetics</topic><topic>Colorectal Neoplasms - metabolism</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Cyclin D1 - metabolism</topic><topic>Cyclin-Dependent Kinase 4 - metabolism</topic><topic>Cyclin-Dependent Kinase Inhibitor p21 - metabolism</topic><topic>Down-Regulation - physiology</topic><topic>Enzyme-Linked Immunosorbent Assay</topic><topic>Flow Cytometry</topic><topic>Fluorescent Antibody Technique</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Immunoenzyme Techniques</topic><topic>Medical sciences</topic><topic>Nuclear Proteins - genetics</topic><topic>Nuclear Proteins - metabolism</topic><topic>Original</topic><topic>Phosphorylation</topic><topic>Reverse Transcriptase Polymerase Chain Reaction</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>RNA-Binding Proteins - genetics</topic><topic>RNA-Binding Proteins - metabolism</topic><topic>Stomach. Duodenum. Small intestine. Colon. Rectum. 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By immuhistochemistry and immunofluorescence, we observed MSP58 in the nucleus and cytoplasm of CRC cells, and found MSP58 to be present in CRC specimens more often than in adjacent non‐tumor tissues (92.5 vs 36.3%, P < 0.01). The average staining score in adjacent non‐tumor tissues was significantly lower than in CRC tissues (2.05 ± 1.13 vs 5.23 ± 1.38, P < 0.01). Moreover, MSP58 mRNA and protein appeared to be upregulated in six fresh CRC samples compared to their adjacent non‐cancerous tissues. MSP58 expression was also detected in the human CRC‐derived cell lines LoVo, CoLo205, HCT116, HT‐29, SW620, and SW480. Downregulation of MSP58 inhibited in vitro growth and attenuated tumor growth in animal models by induction of cell cycle arrest, and was associated with reduced levels of cyclin D1, cyclin‐dependent kinase 4, phosphorylation‐Rb (p‐Rb), p21, and Retino blastoma (Rb) proteins. These results indicated that MSP58 might play an important role in the carcinogenesis of CRC via regulation of the cyclin D1–cyclin‐dependent kinase 4–p21 pathway. (Cancer Sci 2009; 100: 1585–1590)</abstract><cop>Melbourne, Australia</cop><pub>Blackwell Publishing Asia</pub><pmid>19549253</pmid><doi>10.1111/j.1349-7006.2009.01223.x</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Biological and medical sciences Blotting, Western Cell Cycle Cell Proliferation Colony-Forming Units Assay Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cyclin D1 - metabolism Cyclin-Dependent Kinase 4 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Down-Regulation - physiology Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Medical sciences Nuclear Proteins - genetics Nuclear Proteins - metabolism Original Phosphorylation Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Subcellular Fractions Tumor Cells, Cultured Tumors |
| title | Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1–cyclin‐dependent kinase 4–p21 pathway |
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