Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1–cyclin‐dependent kinase 4–p21 pathway

We have investigated the expression and role of the 58‐kDa microspherule protein (MSP58) in colorectal carcinoma (CRC). By immuhistochemistry and immunofluorescence, we observed MSP58 in the nucleus and cytoplasm of CRC cells, and found MSP58 to be present in CRC specimens more often than in adjacen...

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Veröffentlicht in:	Cancer science 2009-09, Vol.100 (9), p.1585-1590
Hauptverfasser:	Shi, Hai, Chen, Sunxiao, Jin, Haifeng, Xu, Chunsheng, Dong, Guanglong, Zhao, Qingchuan, Wang, Weizhong, Zhang, Hongwei, Lin, Wei, Zhang, Jing, Davidovic, Laetitia, Yao, Libo, Fan, Daiming
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological and medical sciences Blotting, Western Cell Cycle Cell Proliferation Colony-Forming Units Assay Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Cyclin D1 - metabolism Cyclin-Dependent Kinase 4 - metabolism Cyclin-Dependent Kinase Inhibitor p21 - metabolism Down-Regulation - physiology Enzyme-Linked Immunosorbent Assay Flow Cytometry Fluorescent Antibody Technique Gastroenterology. Liver. Pancreas. Abdomen Humans Immunoenzyme Techniques Medical sciences Nuclear Proteins - genetics Nuclear Proteins - metabolism Original Phosphorylation Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Subcellular Fractions Tumor Cells, Cultured Tumors
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Zusammenfassung:	We have investigated the expression and role of the 58‐kDa microspherule protein (MSP58) in colorectal carcinoma (CRC). By immuhistochemistry and immunofluorescence, we observed MSP58 in the nucleus and cytoplasm of CRC cells, and found MSP58 to be present in CRC specimens more often than in adjacent non‐tumor tissues (92.5 vs 36.3%, P
ISSN:	1347-9032 1349-7006 1349-7006
DOI:	10.1111/j.1349-7006.2009.01223.x