Comparison of core needle biopsy (CNB) and surgical specimens for accurate preoperative evaluation of ER, PgR and HER2 status of breast cancer patients

The roles of core needle biopsy (CNB) have become well established as an important preoperative diagnostic method for breast lesions. We examined the concordance of histological types, nuclear grades, hormone receptors, and human epidermal growth factor receptor 2 (HER2) status between CNB and surgi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Cancer science 2010-09, Vol.101 (9), p.2074-2079
Hauptverfasser:	Tamaki, Kentaro, Sasano, Hironobu, Ishida, Takanori, Miyashita, Minoru, Takeda, Motohiro, Amari, Masakazu, Tamaki, Nobumitsu, Ohuchi, Noriaki
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biological and medical sciences Biopsy, Needle Breast - chemistry Breast - pathology Breast - surgery Breast Neoplasms - metabolism Breast Neoplasms - pathology Breast Neoplasms - surgery Diagnosis, Differential Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Mammary gland diseases Medical sciences Middle Aged Original Receptor, ErbB-2 - analysis Receptors, Estrogen - analysis Receptors, Progesterone - analysis Sensitivity and Specificity Tumors
Online-Zugang:	Volltext bestellen
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	The roles of core needle biopsy (CNB) have become well established as an important preoperative diagnostic method for breast lesions. We examined the concordance of histological types, nuclear grades, hormone receptors, and human epidermal growth factor receptor 2 (HER2) status between CNB and surgical specimens in 353 cases. In addition, we analyzed the correlation between the number of CNB specimens obtained and accuracy of histological factors in order to explore the optimal number of CNB specimens. Between CNB and surgical specimens, concordance rates of histological type, nuclear grade, estrogen receptor (ER), and progesterone receptor (PgR) status (cut‐off 0–
ISSN:	1347-9032 1349-7006 1349-7006
DOI:	10.1111/j.1349-7006.2010.01630.x