In vitro antiviral activity on dengue virus of marine natural products

Metabolites isolated from marine invertebrates, callipeltin A 1, crambescidin 2, ptilomycalin A 3, celeromycalin 4, gymnochrome B 5, gymnochrome D 6 and isogymnochrome D 7 previously shown bioactive on either herpes simplex virus 1 (2, 3, 4) or human immunodeficiency virus (1, 5, 6, 7), were tested...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 1998-02, Vol.54 (2), p.167-170
Hauptverfasser:	Laille, M, Gerald, F, Debitus, C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiviral agents Antiviral Agents - chemistry antiviral properties aquatic invertebrates Bioassays Cells, Cultured Crinoidea dengue Dengue - drug therapy Dengue fever Dengue virus Dengue Virus - drug effects Dengue virus 1 Echinodermata - chemistry Gymnocrinus richeri Herpes viruses HIV Human herpesvirus 1 Human immunodeficiency virus Living fossils Marine Marine invertebrates Metabolites Molecular Structure Porifera - chemistry Vector-borne diseases Viral Plaque Assay Virology
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Beschreibung
Zusammenfassung:	Metabolites isolated from marine invertebrates, callipeltin A 1, crambescidin 2, ptilomycalin A 3, celeromycalin 4, gymnochrome B 5, gymnochrome D 6 and isogymnochrome D 7 previously shown bioactive on either herpes simplex virus 1 (2, 3, 4) or human immunodeficiency virus (1, 5, 6, 7), were tested on a new in vitro bioassay using the dengue virus 1. Only gymnochrome D and isogymnochrome D isolated from the living fossil crinoid Gymnocrinus richeri are highly potent dengue antiviral agents.
ISSN:	1420-682X 1420-9071
DOI:	10.1007/s000180050138