Trefoil factors: Trefoil factor family 2 deficiency and immune response

The protective effect of Trefoil Factor Family (TFF) proteins in the gastrointestinal tract by promoting the healing of injured mucosa is well known. An increasing body of evidence connects TFFs, especially, TFF2 and TFF3, with a possible role in immune regulation. TFF2 is able to inhibit lipopolysa...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2005-12, Vol.62 (24), p.2947-2955
Hauptverfasser:	Baus-Loncar, M, Kayademir, T, Takaishi, S, Wang, T
Format:	Artikel
Sprache:	eng
Schlagworte:	Gastrointestinal tract Gene expression Immune response Immunoregulation Injuries Leukocyte migration Monocytes Mucosa Multi-author Review Nitric oxide Trefoil factor
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Beschreibung
Zusammenfassung:	The protective effect of Trefoil Factor Family (TFF) proteins in the gastrointestinal tract by promoting the healing of injured mucosa is well known. An increasing body of evidence connects TFFs, especially, TFF2 and TFF3, with a possible role in immune regulation. TFF2 is able to inhibit lipopolysaccharide-induced nitric oxide production in monocytes and can potently limit leukocyte recruitment at the site of injury. An analysis of gene expression in gastrointestinal tissue of TFF2-deficient mice reveals some new aspects of TFF2's role in the immune response.
ISSN:	1420-682X 1420-9071
DOI:	10.1007/s00018-005-5483-7