Antimicrobial agents targeting the ribosome: the issue of selectivity and toxicity - lessons to be learned

A study focuses on the primary problem of contemporary drug development, which is toxicity. ogether with identification of functionally relevant sites in the ribosome, X-ray crystallography, and powerful chemistry, genetics is back at the core of drug development.

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Bibliographische Detailangaben
Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2007-04, Vol.64 (7-8), p.791-795
1. Verfasser:	Boettger, E C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - metabolism Anti-Bacterial Agents - pharmacology Anti-Bacterial Agents - toxicity Antimicrobial agents Bacteria - drug effects Bacteria - genetics Bacteria - metabolism Crystallography Drug Resistance, Bacterial drugs Genetics Humans Pharmacology Protein Synthesis Inhibitors - chemistry Protein Synthesis Inhibitors - metabolism Protein Synthesis Inhibitors - pharmacology Protein Synthesis Inhibitors - toxicity ribosome Ribosomes - drug effects Ribosomes - metabolism RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Bacterial - metabolism RNA, Ribosomal - chemistry RNA, Ribosomal - genetics RNA, Ribosomal - metabolism Toxicity Visions & Reflections (Minireview)
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Beschreibung
Zusammenfassung:	A study focuses on the primary problem of contemporary drug development, which is toxicity. ogether with identification of functionally relevant sites in the ribosome, X-ray crystallography, and powerful chemistry, genetics is back at the core of drug development.
ISSN:	1420-682X 1420-9071
DOI:	10.1007/s00018-007-6431-5