Trimethoprim-Sulfamethoxazole Plus Azithromycin to Prevent Malaria and Sexually Transmitted Infections in Pregnant Women With HIV (PREMISE): A Randomized, Double-Masked, Placebo-Controlled, Phase IIB Clinical Trial

Abstract Background This trial tested the effectiveness of a novel regimen to prevent malaria and sexually transmitted infections (STIs) among pregnant women with HIV in Cameroon. Our hypothesis was that the addition of azithromycin (AZ) to standard daily trimethoprim-sulfamethoxazole (TMP-SMX) prop...

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Veröffentlicht in:	Open Forum Infectious Diseases 2024-05, Vol.11 (5), p.ofae274
Hauptverfasser:	Dionne, Jodie A, Anchang-Kimbi, Judith, Hao, Jiaying, Long, Dustin, Apinjoh, Tobias, Tih, Pius, Mbah, Rahel, Ngah, Edward Ndze, Juliano, Jonathan J, Kahn, Mauricio, Bruxvoort, Katia, Van Der Pol, Barbara, Tita, Alan T N, Marrazzo, Jeanne, Achidi, Eric
Format:	Artikel
Sprache:	eng
Schlagworte:	Azithromycin Clinical trials Clinical Trials and Therapeutics Disease transmission HIV (Viruses) Malaria Metronidazole Patient compliance Plasmodium falciparum Pregnancy Pregnant women Prevention Product development Sexually transmitted diseases Sulfamethoxazole Syphilis Trimethoprim
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Zusammenfassung:	Abstract Background This trial tested the effectiveness of a novel regimen to prevent malaria and sexually transmitted infections (STIs) among pregnant women with HIV in Cameroon. Our hypothesis was that the addition of azithromycin (AZ) to standard daily trimethoprim-sulfamethoxazole (TMP-SMX) prophylaxis would reduce malaria and STI infection rates at delivery. Methods Pregnant women with HIV at gestational age
ISSN:	2328-8957 2328-8957
DOI:	10.1093/ofid/ofae274