Rho-kinase inhibitors as therapeutics: from pan inhibition to isoform selectivity

The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked growing interest in the pharmacological potential of ROCK inhibitors beyond their current application in cardiovascular disease. This articl...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2010-01, Vol.67 (2), p.171-177
Hauptverfasser:	Hahmann, C., Schroeter, T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Cardiovascular diseases Cell Biology Diabetes Mellitus - drug therapy Diabetes Mellitus - enzymology Dogs Genotype & phenotype Glaucoma - drug therapy Glaucoma - enzymology Humans Inhibitors Isoenzymes - antagonists & inhibitors Isoenzymes - chemistry Kidney Diseases - drug therapy Kidney Diseases - enzymology Kinases Life Sciences Mice Neoplasms - drug therapy Neoplasms - enzymology Neurodegeneration Neurodegenerative Diseases - drug therapy Neurodegenerative Diseases - enzymology Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - therapeutic use Proteins Rats rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - chemistry Rocks Visions & Reflections (Minireview)
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Zusammenfassung:	The emerging critical implications of Rho/Rho-kinase (ROCK) signaling in neurodegenerative diseases, glaucoma, renoprotection, diabetes and cancer have sparked growing interest in the pharmacological potential of ROCK inhibitors beyond their current application in cardiovascular disease. This article discusses the therapeutic benefits of novel ROCK inhibitors in development, and highlights the recent advances in the current understanding of disease-dependent and isoform-specific functions of ROCK and their potential impact on future therapeutic strategies.
ISSN:	1420-682X 1420-9071
DOI:	10.1007/s00018-009-0189-x