Critical effects of epigenetic regulation in pulmonary arterial hypertension

Pulmonary arterial hypertension (PAH) is characterized by persistent pulmonary vasoconstriction and pulmonary vascular remodeling. The pathogenic mechanisms of PAH remain to be fully clarified and measures of effective prevention are lacking. Recent studies; however, have indicated that epigenetic p...

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Veröffentlicht in:	Cellular and molecular life sciences : CMLS 2017-10, Vol.74 (20), p.3789-3808
Hauptverfasser:	Chen, Dewei, Gao, Wenxiang, Wang, Shouxian, Ni, Bing, Gao, Yuqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Chromatin Chromatin Assembly and Disassembly Chromatin remodeling Deoxyribonucleic acid DNA DNA Methylation Epigenesis, Genetic Epigenetics Histone Code Humans Hypertension Hypertension, Pulmonary - genetics Hypertension, Pulmonary - metabolism Hypertension, Pulmonary - pathology Life Sciences Pathogenesis Pulmonary arteries Pulmonary hypertension Review RNA, Untranslated - genetics RNA, Untranslated - metabolism Signal Transduction Vasoconstriction Veins & arteries
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Zusammenfassung:	Pulmonary arterial hypertension (PAH) is characterized by persistent pulmonary vasoconstriction and pulmonary vascular remodeling. The pathogenic mechanisms of PAH remain to be fully clarified and measures of effective prevention are lacking. Recent studies; however, have indicated that epigenetic processes may exert pivotal influences on PAH pathogenesis. In this review, we summarize the latest research findings regarding epigenetic regulation in PAH, focusing on the roles of non-coding RNAs, histone modifications, ATP-dependent chromatin remodeling and DNA methylation, and discuss the potential of epigenetic-based therapies for PAH.
ISSN:	1420-682X 1420-9071
DOI:	10.1007/s00018-017-2551-8