Chemokines and Their Receptors: Predictors of Therapeutic Potential in Tumor Microenvironment on Esophageal Cancer

Esophageal carcinoma (ESCA) is an aggressive solid tumor. The 5-year survival rate for patients with ESCA is estimated to be less than 20%, mainly due to tumor invasion and metastasis. Therefore, it is urgent to improve early diagnostic tools and effective treatments for ESCA patients. Tumor microenvironment (TME) enhances the ability of tumor cells to proliferate, migrate, and escape from the immune system, thus promoting the occurrence and development of tumor. TME contains chemokines. Chemokines consist of four major families, which are mainly composed of CC and CXC families. The main purpose of this review is to understand the CC and CXC chemokines and their receptors in ESCA, to improve the understanding of tumorigenesis of ESCA and determine new biomarkers for the diagnosis and prognosis of ESCA. We reviewed the literature on CC and CXC chemokines and their receptors in ESCA identified by PubMed database. This article introduces the general structures and functions of CC, CXC chemokines and their receptors in TME, as well as their roles in the progress of ESCA. Chemokines are involved in the development of ESCA, such as cancer cell invasion, metastasis, angiogenesis, and radioresistance, and are key determinants of disease progression, which have a great impact on patient prognosis and treatment response. In addition, a full understanding of their mechanism of action is essential to further verify that these chemokines and their receptors may serve as biomarkers or therapeutic targets of ESCA. Graphical Abstract The poor prognosis of esophageal cancer is related to the early invasion and metastasis of the tumor. Tumor-associated macrophages are highly correlated with the occurrence, development, severity, and prognosis of esophageal cancer in the tumor microenvironment. Studies have shown that tumor-associated macrophages and esophageal cancer cells in the esophageal cancer microenvironment can secrete a variety of chemokines. A comprehensive analysis of the literature on the relationship between esophageal cancer cells and chemokines found that the binding of these chemokines with corresponding receptors can regulate the growth, migration and invasion, angiogenesis, radiotherapy resistance and leukocyte invasion of the tumor.