A step-by-step guide to fragmenting bundled actin filaments

There has long been conflicting evidence as to how bundled actin filaments, found in cellular structures such as filopodia, are disassembled. In this issue, Chikireddy et al. (https://doi.org/10.1083/jcb.202312106) provide a detailed in vitro analysis of the steps involved in fragmentation of fascin...

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Veröffentlicht in:	The Journal of cell biology 2024-06, Vol.223 (6), p.1
Hauptverfasser:	Kadzik, Rachel S, Kovar, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Actin Cytoskeleton - metabolism Actins - metabolism Animals Carrier Proteins - genetics Carrier Proteins - metabolism Filaments Humans Microfilament Proteins - genetics Microfilament Proteins - metabolism Pseudopodia - metabolism Spotlight
Online-Zugang:	Volltext
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Zusammenfassung:	There has long been conflicting evidence as to how bundled actin filaments, found in cellular structures such as filopodia, are disassembled. In this issue, Chikireddy et al. (https://doi.org/10.1083/jcb.202312106) provide a detailed in vitro analysis of the steps involved in fragmentation of fascin-bundled actin filaments and propose a novel mechanism for severing two-filament bundles.
ISSN:	0021-9525 1540-8140 1540-8140
DOI:	10.1083/jcb.202403191