Utility of diffusion tensor imaging and generalized q-sampling imaging for predicting short-term clinical effect of deep brain stimulation in Parkinson’s disease

Purpose To assess whether diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI) metrics could preoperatively predict the clinical outcome of deep brain stimulation (DBS) in patients with Parkinson’s disease (PD). Methods In this single-center retrospective study, from September 202...

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Veröffentlicht in:Acta neurochirurgica 2024-05, Vol.166 (1), p.217-217, Article 217
Hauptverfasser: Yuzkan, Sabahattin, Hasimoglu, Ozan, Balsak, Serdar, Mutlu, Samet, Karagulle, Mehmet, Kose, Fadime, Altinkaya, Ayca, Tugcu, Bekir, Kocak, Burak
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Sprache:eng
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Zusammenfassung:Purpose To assess whether diffusion tensor imaging (DTI) and generalized q-sampling imaging (GQI) metrics could preoperatively predict the clinical outcome of deep brain stimulation (DBS) in patients with Parkinson’s disease (PD). Methods In this single-center retrospective study, from September 2021 to March 2023, preoperative DTI and GQI examinations of 44 patients who underwent DBS surgery, were analyzed. To evaluate motor functions, the Unified Parkinson’s Disease Rating Scale (UPDRS) during on- and off-medication and Parkinson’s Disease Questionnaire-39 (PDQ-39) scales were used before and three months after DBS surgery. The study population was divided into two groups according to the improvement rate of scales: ≥ 50% and 
ISSN:0942-0940
0001-6268
0942-0940
DOI:10.1007/s00701-024-06096-w