Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today

Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits not only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Stu...

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Veröffentlicht in:Kidney international 2024-02, Vol.105 (2), p.218-230
Hauptverfasser: Trachtman, Howard, Desmond, Hailey, Williams, Amanda L., Mariani, Laura H., Eddy, Sean, Ju, Wenjun, Barisoni, Laura, Ascani, Heather K., Uhlmann, Wendy R., Holzman, Lawrence B., Sedor, John R., Subramanian, Lalita, Manieri, Tina, Roberts, Scott J., Gipson, Debbie S., Kretzler, Matthias, Massengill, Susan, Lo, Layla, Sedor, John, Sharma, Silpa, Vento, Suzanne, Canetta, Pietro, Gbadegesin, Rasheed, Smith, Maurice, Wang, Chia-shi, Yun, Emily, Adler, Sharon, Amarah, Amatur, Williams, Miahje, Lieske, John, Hogan, Marie, Fervenza, Fernando, Alston, Cheryl, Reidy, Kim, Zhdanova, Olga, Pehrson, Laura Jane, Miranda, Melanie, Dave, Shiktij, Batla, Sadaf, Ling, Paul, Dylewski, James, Rogers, Nathan, Fornoni, Alessia, Williams, A., Ni, Roxy, Rheault, Michelle, Kowalski, Amy, Derebail, Vimal, Froment, Anne, Meyers, Kevin, Kallem, Krishna, Edwards, Aliya, Sharma, Samin, Sambandam, Kamalanathan, Brown, Elizabeth, Jefferson, Ashley, Tuttle, Katherine, Manahan, Linda, Kuykendall, Kelli, Dharnidharka, Vikas, Salmon, Eloise, Alter, Gabrielle, Arbit, Michael, Larkina, Maria, Scherr, Rebecca, Troost, Jonathan, Williams, Amanda, Zhai, Yan, Kincaid, Colleen, Li, Shengqian, Li, Shannon, Gadegbeku, Crystal, Zee, Jarcy, Bagnasco, Serena, Bu, Lihong, Caltharp, Shelley, Cassol, Clarissa, Demeke, Dawit, Hassler, Jared, Herlitz, Leal, Hewitt, Stephen, Hodgin, Jeff, Holanda, Danni, Kambham, Neeraja, Lemley, Kevin, Messias, Nidia, Mikhailov, Alexei, Moreno, Vanessa, Najafian, Behzad, Rosenberg, Avi, Sekulik, Miroslav, Thomas, David, Wu, Ming, Yamashita, Michifumi, Yin, Hong, Zuo . Cochairs, Yiqin, Nast, Cynthia
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container_end_page 230
container_issue 2
container_start_page 218
container_title Kidney international
container_volume 105
creator Trachtman, Howard
Desmond, Hailey
Williams, Amanda L.
Mariani, Laura H.
Eddy, Sean
Ju, Wenjun
Barisoni, Laura
Ascani, Heather K.
Uhlmann, Wendy R.
Holzman, Lawrence B.
Sedor, John R.
Subramanian, Lalita
Manieri, Tina
Roberts, Scott J.
Gipson, Debbie S.
Kretzler, Matthias
Massengill, Susan
Lo, Layla
Sedor, John
Sharma, Silpa
Vento, Suzanne
Canetta, Pietro
Gbadegesin, Rasheed
Smith, Maurice
Wang, Chia-shi
Yun, Emily
Adler, Sharon
Amarah, Amatur
Williams, Miahje
Lieske, John
Hogan, Marie
Fervenza, Fernando
Alston, Cheryl
Reidy, Kim
Zhdanova, Olga
Pehrson, Laura Jane
Miranda, Melanie
Dave, Shiktij
Batla, Sadaf
Ling, Paul
Dylewski, James
Rogers, Nathan
Fornoni, Alessia
Williams, A.
Ni, Roxy
Rheault, Michelle
Kowalski, Amy
Derebail, Vimal
Froment, Anne
Meyers, Kevin
Kallem, Krishna
Edwards, Aliya
Sharma, Samin
Sambandam, Kamalanathan
Brown, Elizabeth
Jefferson, Ashley
Tuttle, Katherine
Manahan, Linda
Kuykendall, Kelli
Dharnidharka, Vikas
Salmon, Eloise
Trachtman, Howard
Alter, Gabrielle
Arbit, Michael
Eddy, Sean
Larkina, Maria
Scherr, Rebecca
Troost, Jonathan
Williams, Amanda
Zhai, Yan
Kincaid, Colleen
Li, Shengqian
Li, Shannon
Gadegbeku, Crystal
Barisoni, Laura
Zee, Jarcy
Bagnasco, Serena
Bu, Lihong
Caltharp, Shelley
Cassol, Clarissa
Demeke, Dawit
Hassler, Jared
Herlitz, Leal
Hewitt, Stephen
Hodgin, Jeff
Holanda, Danni
Kambham, Neeraja
Lemley, Kevin
Messias, Nidia
Mikhailov, Alexei
Moreno, Vanessa
Najafian, Behzad
Rosenberg, Avi
Sekulik, Miroslav
Thomas, David
Wu, Ming
Yamashita, Michifumi
Yin, Hong
Zuo . Cochairs, Yiqin
Nast, Cynthia
description Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits not only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) is poised to address these challenges. The study has enrolled >850 pediatric and adult patients with proteinuric glomerular diseases who have contributed to deep clinical, histologic, genetic, and molecular profiles linked to long-term outcomes. The NEPTUNE Knowledge Network, comprising combined, multiscalar data sets, captures each participant’s molecular disease processes at the time of kidney biopsy. In this editorial, we describe the design and implementation of NEPTUNE Match, which bridges a basic science discovery pipeline with targeted clinical trials. Noninvasive biomarkers have been developed for real-time pathway analyses. A Molecular Nephrology Board reviews the pathway maps together with clinical, laboratory, and histopathologic data assembled for each patient to compile a Match report that estimates the fit between the specific molecular disease pathway(s) identified in an individual patient and proposed clinical trials. The NEPTUNE Match report is communicated using established protocols to the patient and the attending nephrologist for use in their selection of available clinical trials. NEPTUNE Match represents the first application of precision medicine in nephrology with the aim of developing targeted therapies and providing the right medication for each patient with primary glomerular disease.
doi_str_mv 10.1016/j.kint.2023.11.018
format Article
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Cochairs, Yiqin ; Nast, Cynthia ; NEPTUNE investigators</creatorcontrib><description>Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits not only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) is poised to address these challenges. The study has enrolled &gt;850 pediatric and adult patients with proteinuric glomerular diseases who have contributed to deep clinical, histologic, genetic, and molecular profiles linked to long-term outcomes. The NEPTUNE Knowledge Network, comprising combined, multiscalar data sets, captures each participant’s molecular disease processes at the time of kidney biopsy. In this editorial, we describe the design and implementation of NEPTUNE Match, which bridges a basic science discovery pipeline with targeted clinical trials. Noninvasive biomarkers have been developed for real-time pathway analyses. A Molecular Nephrology Board reviews the pathway maps together with clinical, laboratory, and histopathologic data assembled for each patient to compile a Match report that estimates the fit between the specific molecular disease pathway(s) identified in an individual patient and proposed clinical trials. The NEPTUNE Match report is communicated using established protocols to the patient and the attending nephrologist for use in their selection of available clinical trials. NEPTUNE Match represents the first application of precision medicine in nephrology with the aim of developing targeted therapies and providing the right medication for each patient with primary glomerular disease.</description><identifier>ISSN: 0085-2538</identifier><identifier>ISSN: 1523-1755</identifier><identifier>EISSN: 1523-1755</identifier><identifier>DOI: 10.1016/j.kint.2023.11.018</identifier><identifier>PMID: 38245210</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Biomarkers ; Child ; clinical trials ; Clinical Trials as Topic ; disease pathway ; Humans ; Kidney Diseases ; Kidney Glomerulus - pathology ; Nephrotic Syndrome - diagnosis ; Nephrotic Syndrome - genetics ; Nephrotic Syndrome - therapy ; patient communication</subject><ispartof>Kidney international, 2024-02, Vol.105 (2), p.218-230</ispartof><rights>2023 International Society of Nephrology</rights><rights>Copyright © 2023 International Society of Nephrology. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c456t-e6a5c9450dd30ec0e8cdbd4db597fb06d8835df9cae560d10f0482d1678ffdc73</citedby><cites>FETCH-LOGICAL-c456t-e6a5c9450dd30ec0e8cdbd4db597fb06d8835df9cae560d10f0482d1678ffdc73</cites><orcidid>0000-0003-4064-0582</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38245210$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Trachtman, Howard</creatorcontrib><creatorcontrib>Desmond, Hailey</creatorcontrib><creatorcontrib>Williams, Amanda L.</creatorcontrib><creatorcontrib>Mariani, Laura H.</creatorcontrib><creatorcontrib>Eddy, 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Neeraja</creatorcontrib><creatorcontrib>Lemley, Kevin</creatorcontrib><creatorcontrib>Messias, Nidia</creatorcontrib><creatorcontrib>Mikhailov, Alexei</creatorcontrib><creatorcontrib>Moreno, Vanessa</creatorcontrib><creatorcontrib>Najafian, Behzad</creatorcontrib><creatorcontrib>Rosenberg, Avi</creatorcontrib><creatorcontrib>Sekulik, Miroslav</creatorcontrib><creatorcontrib>Thomas, David</creatorcontrib><creatorcontrib>Wu, Ming</creatorcontrib><creatorcontrib>Yamashita, Michifumi</creatorcontrib><creatorcontrib>Yin, Hong</creatorcontrib><creatorcontrib>Zuo . Cochairs, Yiqin</creatorcontrib><creatorcontrib>Nast, Cynthia</creatorcontrib><creatorcontrib>NEPTUNE investigators</creatorcontrib><title>Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today</title><title>Kidney international</title><addtitle>Kidney Int</addtitle><description>Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits not only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) is poised to address these challenges. The study has enrolled &gt;850 pediatric and adult patients with proteinuric glomerular diseases who have contributed to deep clinical, histologic, genetic, and molecular profiles linked to long-term outcomes. The NEPTUNE Knowledge Network, comprising combined, multiscalar data sets, captures each participant’s molecular disease processes at the time of kidney biopsy. In this editorial, we describe the design and implementation of NEPTUNE Match, which bridges a basic science discovery pipeline with targeted clinical trials. Noninvasive biomarkers have been developed for real-time pathway analyses. A Molecular Nephrology Board reviews the pathway maps together with clinical, laboratory, and histopathologic data assembled for each patient to compile a Match report that estimates the fit between the specific molecular disease pathway(s) identified in an individual patient and proposed clinical trials. The NEPTUNE Match report is communicated using established protocols to the patient and the attending nephrologist for use in their selection of available clinical trials. NEPTUNE Match represents the first application of precision medicine in nephrology with the aim of developing targeted therapies and providing the right medication for each patient with primary glomerular disease.</description><subject>Adult</subject><subject>Biomarkers</subject><subject>Child</subject><subject>clinical trials</subject><subject>Clinical Trials as Topic</subject><subject>disease pathway</subject><subject>Humans</subject><subject>Kidney Diseases</subject><subject>Kidney Glomerulus - pathology</subject><subject>Nephrotic Syndrome - diagnosis</subject><subject>Nephrotic Syndrome - genetics</subject><subject>Nephrotic Syndrome - therapy</subject><subject>patient communication</subject><issn>0085-2538</issn><issn>1523-1755</issn><issn>1523-1755</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kd1uEzEQhS0EoqHwAlwgX7YSu7W96_1BSBWqwo9UAqLtteXYs7tON3awvUV5Fl4Wh6RVueHKGs-ZM0fzIfSakpwSWp2t8ltjY84IK3JKc0KbJ2hGOSsyWnP-FM0IaXjGeNEcoRchrEiq24I8R0dFw0rOKJmh3z9kNM7KEbC0GmsIprfYdTgOgBewGbyLRuGrrdXerQFfxUlvUyP-cv4Wnyzm369vFvNT_FVGNWBjcT8mmZ9G6bE2AWSA8O5ga2z_19abfog4eiNH3Dn_6G-TwoCNb3F0Wm5fomedHAO8OrzH6Obj_Pric3b57dOXiw-XmSp5FTOoJFdtyYnWBQFFoFF6qUu95G3dLUmlm6bgumuVBF4RTUlHyoZpWtVN12lVF8fofO-7mZZr0Col8HIUG2_W0m-Fk0b827FmEL27E5SSllSsSg4nBwfvfk4QoliboGAcpQU3BcHaHZGqrIskZXup8i4ED93DHkrEDqtYiR1WscOaNoiENQ29eZzwYeSeYxK83wsg3enOgBdBpUsq0MaDikI78z__P2aEt8A</recordid><startdate>202402</startdate><enddate>202402</enddate><creator>Trachtman, Howard</creator><creator>Desmond, Hailey</creator><creator>Williams, Amanda L.</creator><creator>Mariani, Laura H.</creator><creator>Eddy, Sean</creator><creator>Ju, Wenjun</creator><creator>Barisoni, Laura</creator><creator>Ascani, Heather K.</creator><creator>Uhlmann, Wendy R.</creator><creator>Holzman, Lawrence B.</creator><creator>Sedor, John R.</creator><creator>Subramanian, Lalita</creator><creator>Manieri, Tina</creator><creator>Roberts, Scott J.</creator><creator>Gipson, Debbie S.</creator><creator>Kretzler, Matthias</creator><creator>Massengill, Susan</creator><creator>Lo, Layla</creator><creator>Sedor, John</creator><creator>Sharma, Silpa</creator><creator>Vento, Suzanne</creator><creator>Canetta, Pietro</creator><creator>Gbadegesin, Rasheed</creator><creator>Smith, Maurice</creator><creator>Wang, Chia-shi</creator><creator>Yun, Emily</creator><creator>Adler, Sharon</creator><creator>Amarah, Amatur</creator><creator>Williams, Miahje</creator><creator>Lieske, John</creator><creator>Hogan, Marie</creator><creator>Fervenza, Fernando</creator><creator>Alston, Cheryl</creator><creator>Reidy, Kim</creator><creator>Zhdanova, Olga</creator><creator>Pehrson, Laura Jane</creator><creator>Miranda, Melanie</creator><creator>Dave, Shiktij</creator><creator>Batla, Sadaf</creator><creator>Ling, Paul</creator><creator>Dylewski, James</creator><creator>Rogers, Nathan</creator><creator>Fornoni, Alessia</creator><creator>Williams, A.</creator><creator>Ni, Roxy</creator><creator>Rheault, Michelle</creator><creator>Kowalski, Amy</creator><creator>Derebail, Vimal</creator><creator>Froment, Anne</creator><creator>Meyers, Kevin</creator><creator>Kallem, Krishna</creator><creator>Edwards, Aliya</creator><creator>Sharma, Samin</creator><creator>Sambandam, Kamalanathan</creator><creator>Brown, Elizabeth</creator><creator>Jefferson, Ashley</creator><creator>Tuttle, Katherine</creator><creator>Manahan, Linda</creator><creator>Kuykendall, Kelli</creator><creator>Dharnidharka, Vikas</creator><creator>Salmon, Eloise</creator><creator>Trachtman, Howard</creator><creator>Alter, Gabrielle</creator><creator>Arbit, Michael</creator><creator>Eddy, Sean</creator><creator>Larkina, Maria</creator><creator>Scherr, Rebecca</creator><creator>Troost, Jonathan</creator><creator>Williams, Amanda</creator><creator>Zhai, Yan</creator><creator>Kincaid, Colleen</creator><creator>Li, Shengqian</creator><creator>Li, Shannon</creator><creator>Gadegbeku, Crystal</creator><creator>Barisoni, Laura</creator><creator>Zee, Jarcy</creator><creator>Bagnasco, Serena</creator><creator>Bu, Lihong</creator><creator>Caltharp, Shelley</creator><creator>Cassol, Clarissa</creator><creator>Demeke, Dawit</creator><creator>Hassler, Jared</creator><creator>Herlitz, Leal</creator><creator>Hewitt, Stephen</creator><creator>Hodgin, Jeff</creator><creator>Holanda, Danni</creator><creator>Kambham, Neeraja</creator><creator>Lemley, Kevin</creator><creator>Messias, Nidia</creator><creator>Mikhailov, Alexei</creator><creator>Moreno, Vanessa</creator><creator>Najafian, Behzad</creator><creator>Rosenberg, Avi</creator><creator>Sekulik, Miroslav</creator><creator>Thomas, David</creator><creator>Wu, Ming</creator><creator>Yamashita, Michifumi</creator><creator>Yin, Hong</creator><creator>Zuo . Cochairs, Yiqin</creator><creator>Nast, Cynthia</creator><general>Elsevier Inc</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4064-0582</orcidid></search><sort><creationdate>202402</creationdate><title>Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today</title><author>Trachtman, Howard ; Desmond, Hailey ; Williams, Amanda L. ; Mariani, Laura H. ; Eddy, Sean ; Ju, Wenjun ; Barisoni, Laura ; Ascani, Heather K. ; Uhlmann, Wendy R. ; Holzman, Lawrence B. ; Sedor, John R. ; Subramanian, Lalita ; Manieri, Tina ; Roberts, Scott J. ; Gipson, Debbie S. ; Kretzler, Matthias ; Massengill, Susan ; Lo, Layla ; Sedor, John ; Sharma, Silpa ; Vento, Suzanne ; Canetta, Pietro ; Gbadegesin, Rasheed ; Smith, Maurice ; Wang, Chia-shi ; Yun, Emily ; Adler, Sharon ; Amarah, Amatur ; Williams, Miahje ; Lieske, John ; Hogan, Marie ; Fervenza, Fernando ; Alston, Cheryl ; Reidy, Kim ; Zhdanova, Olga ; Pehrson, Laura Jane ; Miranda, Melanie ; Dave, Shiktij ; Batla, Sadaf ; Ling, Paul ; Dylewski, James ; Rogers, Nathan ; Fornoni, Alessia ; Williams, A. ; Ni, Roxy ; Rheault, Michelle ; Kowalski, Amy ; Derebail, Vimal ; Froment, Anne ; Meyers, Kevin ; Kallem, Krishna ; Edwards, Aliya ; Sharma, Samin ; Sambandam, Kamalanathan ; Brown, Elizabeth ; Jefferson, Ashley ; Tuttle, Katherine ; Manahan, Linda ; Kuykendall, Kelli ; Dharnidharka, Vikas ; Salmon, Eloise ; Trachtman, Howard ; Alter, Gabrielle ; Arbit, Michael ; Eddy, Sean ; Larkina, Maria ; Scherr, Rebecca ; Troost, Jonathan ; Williams, Amanda ; Zhai, Yan ; Kincaid, Colleen ; Li, Shengqian ; Li, Shannon ; Gadegbeku, Crystal ; Barisoni, Laura ; Zee, Jarcy ; Bagnasco, Serena ; Bu, Lihong ; Caltharp, Shelley ; Cassol, Clarissa ; Demeke, Dawit ; Hassler, Jared ; Herlitz, Leal ; Hewitt, Stephen ; Hodgin, Jeff ; Holanda, Danni ; Kambham, Neeraja ; Lemley, Kevin ; Messias, Nidia ; Mikhailov, Alexei ; Moreno, Vanessa ; Najafian, Behzad ; Rosenberg, Avi ; Sekulik, Miroslav ; Thomas, David ; Wu, Ming ; Yamashita, Michifumi ; Yin, Hong ; Zuo . 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Cochairs, Yiqin</creatorcontrib><creatorcontrib>Nast, Cynthia</creatorcontrib><creatorcontrib>NEPTUNE investigators</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Kidney international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Trachtman, Howard</au><au>Desmond, Hailey</au><au>Williams, Amanda L.</au><au>Mariani, Laura H.</au><au>Eddy, Sean</au><au>Ju, Wenjun</au><au>Barisoni, Laura</au><au>Ascani, Heather K.</au><au>Uhlmann, Wendy R.</au><au>Holzman, Lawrence B.</au><au>Sedor, John R.</au><au>Subramanian, Lalita</au><au>Manieri, Tina</au><au>Roberts, Scott J.</au><au>Gipson, Debbie S.</au><au>Kretzler, Matthias</au><au>Massengill, Susan</au><au>Lo, Layla</au><au>Sedor, John</au><au>Sharma, Silpa</au><au>Vento, Suzanne</au><au>Canetta, Pietro</au><au>Gbadegesin, Rasheed</au><au>Smith, Maurice</au><au>Wang, Chia-shi</au><au>Yun, Emily</au><au>Adler, Sharon</au><au>Amarah, Amatur</au><au>Williams, Miahje</au><au>Lieske, John</au><au>Hogan, Marie</au><au>Fervenza, Fernando</au><au>Alston, Cheryl</au><au>Reidy, Kim</au><au>Zhdanova, Olga</au><au>Pehrson, Laura Jane</au><au>Miranda, Melanie</au><au>Dave, Shiktij</au><au>Batla, Sadaf</au><au>Ling, Paul</au><au>Dylewski, James</au><au>Rogers, Nathan</au><au>Fornoni, Alessia</au><au>Williams, A.</au><au>Ni, Roxy</au><au>Rheault, Michelle</au><au>Kowalski, Amy</au><au>Derebail, Vimal</au><au>Froment, Anne</au><au>Meyers, Kevin</au><au>Kallem, Krishna</au><au>Edwards, Aliya</au><au>Sharma, Samin</au><au>Sambandam, Kamalanathan</au><au>Brown, Elizabeth</au><au>Jefferson, Ashley</au><au>Tuttle, Katherine</au><au>Manahan, Linda</au><au>Kuykendall, Kelli</au><au>Dharnidharka, Vikas</au><au>Salmon, Eloise</au><au>Trachtman, Howard</au><au>Alter, Gabrielle</au><au>Arbit, Michael</au><au>Eddy, Sean</au><au>Larkina, Maria</au><au>Scherr, Rebecca</au><au>Troost, Jonathan</au><au>Williams, Amanda</au><au>Zhai, Yan</au><au>Kincaid, Colleen</au><au>Li, Shengqian</au><au>Li, Shannon</au><au>Gadegbeku, Crystal</au><au>Barisoni, Laura</au><au>Zee, Jarcy</au><au>Bagnasco, Serena</au><au>Bu, Lihong</au><au>Caltharp, Shelley</au><au>Cassol, Clarissa</au><au>Demeke, Dawit</au><au>Hassler, Jared</au><au>Herlitz, Leal</au><au>Hewitt, Stephen</au><au>Hodgin, Jeff</au><au>Holanda, Danni</au><au>Kambham, Neeraja</au><au>Lemley, Kevin</au><au>Messias, Nidia</au><au>Mikhailov, Alexei</au><au>Moreno, Vanessa</au><au>Najafian, Behzad</au><au>Rosenberg, Avi</au><au>Sekulik, Miroslav</au><au>Thomas, David</au><au>Wu, Ming</au><au>Yamashita, Michifumi</au><au>Yin, Hong</au><au>Zuo . Cochairs, Yiqin</au><au>Nast, Cynthia</au><aucorp>NEPTUNE investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today</atitle><jtitle>Kidney international</jtitle><addtitle>Kidney Int</addtitle><date>2024-02</date><risdate>2024</risdate><volume>105</volume><issue>2</issue><spage>218</spage><epage>230</epage><pages>218-230</pages><issn>0085-2538</issn><issn>1523-1755</issn><eissn>1523-1755</eissn><abstract>Glomerular diseases are classified using a descriptive taxonomy that is not reflective of the heterogeneous underlying molecular drivers. This limits not only diagnostic and therapeutic patient management, but also impacts clinical trials evaluating targeted interventions. The Nephrotic Syndrome Study Network (NEPTUNE) is poised to address these challenges. The study has enrolled &gt;850 pediatric and adult patients with proteinuric glomerular diseases who have contributed to deep clinical, histologic, genetic, and molecular profiles linked to long-term outcomes. The NEPTUNE Knowledge Network, comprising combined, multiscalar data sets, captures each participant’s molecular disease processes at the time of kidney biopsy. In this editorial, we describe the design and implementation of NEPTUNE Match, which bridges a basic science discovery pipeline with targeted clinical trials. Noninvasive biomarkers have been developed for real-time pathway analyses. A Molecular Nephrology Board reviews the pathway maps together with clinical, laboratory, and histopathologic data assembled for each patient to compile a Match report that estimates the fit between the specific molecular disease pathway(s) identified in an individual patient and proposed clinical trials. The NEPTUNE Match report is communicated using established protocols to the patient and the attending nephrologist for use in their selection of available clinical trials. NEPTUNE Match represents the first application of precision medicine in nephrology with the aim of developing targeted therapies and providing the right medication for each patient with primary glomerular disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>38245210</pmid><doi>10.1016/j.kint.2023.11.018</doi><tpages>13</tpages><orcidid>https://orcid.org/0000-0003-4064-0582</orcidid><oa>free_for_read</oa></addata></record>
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ispartof Kidney international, 2024-02, Vol.105 (2), p.218-230
issn 0085-2538
1523-1755
1523-1755
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11090626
source MEDLINE; Alma/SFX Local Collection
subjects Adult
Biomarkers
Child
clinical trials
Clinical Trials as Topic
disease pathway
Humans
Kidney Diseases
Kidney Glomerulus - pathology
Nephrotic Syndrome - diagnosis
Nephrotic Syndrome - genetics
Nephrotic Syndrome - therapy
patient communication
title Rationale and design of the Nephrotic Syndrome Study Network (NEPTUNE) Match in glomerular diseases: designing the right trial for the right patient, today
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