Basement membrane dynamics in living animals: Insights and pitfalls

Recent studies with fluorophore-tagged basement membrane (BM) components have led to remarkable discoveries about BMs but also inconsistent interpretations. Here, we review types of BM dynamics, discuss how we conduct and interpret fluorophore-tagged BM studies, and highlight experimental conditions...

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Veröffentlicht in:	The Journal of cell biology 2024-07, Vol.223 (7), p.1
Hauptverfasser:	Stramer, Brian M, Sherwood, David R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basement Membrane - metabolism Basement membranes Development Fluorescent Dyes - chemistry Humans Viewpoint
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Recent studies with fluorophore-tagged basement membrane (BM) components have led to remarkable discoveries about BMs but also inconsistent interpretations. Here, we review types of BM dynamics, discuss how we conduct and interpret fluorophore-tagged BM studies, and highlight experimental conditions that are important to consider.
ISSN:	0021-9525 1540-8140 1540-8140
DOI:	10.1083/jcb.202402113