Comparison of Orthotopic and Heterotopic Autologous Ovarian Tissue Transplantation (OTT) Outcomes

To compare the outcomes of orthotopic and heterotopic ovarian tissue transplantation techniques. Mixed Prospective-Retrospective cohort study 14 recipients of autologous ovarian tissue transplantation Of the 14 women, 12 who received orthotopic (n=6) or heterotopic (n=6) transplants met the inclusion criteria. All orthotopic transplants and one heterotopic ovarian tissue transplant were performed laparoscopically. While five of six remaining heterotopic transplants were performed subcutaneously under local anesthesia or iv sedation, one was performed with robotic assistance. With the exception of one recipient who solely desired restoration of endocrine function, all underwent oocyte retrieval either to cryopreserve oocytes/embryos before the graft function ceased or because they could not otherwise conceive (hysterectomy, radiation damage, heterotopic transplant). Primary outcome measures were graft function and longevity, and number embryos generated per retrieval. The mean age at ovarian tissue harvesting and at transplantation was lower in the orthotopic vs heterotopic transplant patients, (p