Histone methyltransferase SETD2 is required for proper hippocampal lamination and neuronal maturation

Proper formation of the hippocampus is crucial for the brain to execute memory and learning functions. However, many questions remain regarding how pyramidal neurons (PNs) of the hippocampus mature and precisely position. Here we revealed that , the methyltransferase for histone 3 lysine 36 trimethylation (H3K36me3), is essential for the precise localization and maturation of PNs in the hippocampal CA1. The ablation of in neural progenitors leads to irregular lamination of the CA1 and increased numbers of PNs in the stratum oriens. deletion in postmitotic neurons causes mislocalization and immaturity of CA1 PNs. Transcriptome analyses revealed that SETD2 maintains the expressions of clustered protocadherin ( ) genes. Together, is required for proper hippocampal lamination and maturation of CA1 PNs.