The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation

The sparing effect of FLASH-RT on synaptic plasticity is maintained in mice with standard fractionation

•FLASH sparing in the brain can be achieved under standard fractionation.•Long-term potentiation (LTP) is sensitive to dose-rate modulation.•LTP measures synaptic plasticity and is impaired after CONV-RT but not FLASH-RT. Long-term potentiation (LTP) was used to gauge the impact of conventional and...

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Veröffentlicht in:Radiotherapy and oncology 2023-09, Vol.186, p.109767-109767, Article 109767
Hauptverfasser: Limoli, Charles L., Kramár, Eniko A., Almeida, Aymeric, Petit, Benoit, Grilj, Veljko, Baulch, Janet E., Ballesteros-Zebadua, Paola, Loo, Billy W, Wood, Marcelo A., Vozenin, Marie-Catherine
Format: Artikel
Sprache:eng
Schlagworte:
Animals
FLASH radiotherapy
Hippocampus - physiology
Long-term potentiation
Long-Term Potentiation - physiology
Mice
Neuronal Plasticity - physiology
Standard-of care fractionation
Synaptic Transmission - physiology
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Zusammenfassung:•FLASH sparing in the brain can be achieved under standard fractionation.•Long-term potentiation (LTP) is sensitive to dose-rate modulation.•LTP measures synaptic plasticity and is impaired after CONV-RT but not FLASH-RT. Long-term potentiation (LTP) was used to gauge the impact of conventional and FLASH dose rates on synaptic transmission. Data collected from the hippocampus and medial prefrontal cortex confirmed significant inhibition of LTP after 10 fractions of 3 Gy (30 Gy total) conventional radiotherapy. Remarkably, 10x3Gy FLASH radiotherapy and unirradiated controls were identical and exhibited normal LTP.
ISSN:0167-8140
1879-0887
DOI:10.1016/j.radonc.2023.109767