Nitric oxide inhibits proliferation but increases life-span of T lymphocytes in tumour-bearing rats

Nitric oxide inhibits proliferation but increases life-span of T lymphocytes in tumour-bearing rats

Nitric oxide (NO) has been shown to inhibit the proliferation of lymphocytes. However, in tumour-bearing rats treated with the immunomodulator OM 163, the regressing nodules were heavily infiltrated by T lymphocytes, although they contained high levels of NO. We show here that NO, while inhibiting t...

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Veröffentlicht in:Cancer Immunology, Immunotherapy Immunotherapy, 1998-05, Vol.46 (3), p.160-166
Hauptverfasser: REISSER, D, LAGADEC, P, ARNOULD, L, ONIER, N, MAUPOIL, V, PINARD, D, JEANNIN, J.-F
Format: Artikel
Sprache:eng
Schlagworte:
Adjuvants, Immunologic - therapeutic use
Animals
Antineoplastic agents
Antineoplastic Agents - therapeutic use
Biological and medical sciences
Carcinoma - immunology
Carcinoma - therapy
Cell Survival - drug effects
Escherichia coli
Immunotherapy
Lymphocyte Activation - drug effects
Medical sciences
Nitric Oxide - biosynthesis
Nitric Oxide - pharmacology
Original
Peritoneal Neoplasms - immunology
Peritoneal Neoplasms - therapy
Pharmacology. Drug treatments
Rats
T-Lymphocytes - cytology
T-Lymphocytes - immunology
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Zusammenfassung:Nitric oxide (NO) has been shown to inhibit the proliferation of lymphocytes. However, in tumour-bearing rats treated with the immunomodulator OM 163, the regressing nodules were heavily infiltrated by T lymphocytes, although they contained high levels of NO. We show here that NO, while inhibiting the proliferation of lymphocytes, increased their life-span, pointing to the ambivalence of this molecule in the course of tumour growth and regression.
ISSN:0340-7004
1432-0851
DOI:10.1007/s002620050474