Imaging characterization of paediatric tumours with the neurotrophic tyrosine receptor kinase fusion transcript

The neurotrophic tyrosine receptor kinase (NTRK) fusion transcript (FT) is a major genetic landmark of infantile fibrosarcoma (IFS) and cellular congenital mesoblastic nephroma (cCMN) but is also described in other tumours. The recent availability of NTRK-targeted drugs enhances the need for better...

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Veröffentlicht in:	British journal of radiology 2024-03, Vol.97 (1156), p.734-743
Hauptverfasser:	Hermann, Anne-Laure, Lemelle, Lauriane, Pierron, Gaëlle, Gauthier, Arnaud, Nicolas, Nayla, Cardoen, Liesbeth, Moalla, Salma, Petit, Philippe, Morel, Baptiste, Ducou Le Pointe, Hubert, Hassani, Adnan, Fréneaux, Paul, Guillemot, Delphine, Carton, Matthieu, Corradini, Nadège, Rome, Angélique, Castex, Marie-Pierre, Defachelles, Anne-Sophie, Schleiermacher, Gudrun, Berlanga, Pablo, Delattre, Olivier, Orbach, Daniel, Brisse, Hervé J
Format:	Artikel
Sprache:	eng
Schlagworte:	Child Fibrosarcoma - genetics Fibrosarcoma - pathology Humans Infant Kidney Neoplasms - diagnostic imaging Kidney Neoplasms - genetics Nephroma, Mesoblastic - congenital Nephroma, Mesoblastic - genetics Nephroma, Mesoblastic - pathology Pictorial Review Receptors, Amino Acid Retrospective Studies
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Zusammenfassung:	The neurotrophic tyrosine receptor kinase (NTRK) fusion transcript (FT) is a major genetic landmark of infantile fibrosarcoma (IFS) and cellular congenital mesoblastic nephroma (cCMN) but is also described in other tumours. The recent availability of NTRK-targeted drugs enhances the need for better identification. We aimed to describe the anatomic locations and imaging features of tumours with NTRK-FT in children. Imaging characteristics of NTRK-FT tumours of 41 children (median age: 4 months; 63%
ISSN:	0007-1285 1748-880X 1748-880X
DOI:	10.1093/bjr/tqae016