Are you angry? Neural basis of impaired facial expression recognition in pre-manifest Huntington's

Early non-motor symptoms in Huntington's disease (HD), including visual perceptual difficulties, can have profound negative impacts on quality of life. In particular, deficits in emotion recognition may contribute to misinterpretation of social cues, and may adversely affect interpersonal relat...

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Veröffentlicht in:Parkinsonism & related disorders 2023-04, Vol.109, p.105289-105289, Article 105289
Hauptverfasser: Rosas, H. Diana, Lewis, Lydia, Connors, Natalie, Mercaldo, Nathaniel D., Nasr, Shahin
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Sprache:eng
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Zusammenfassung:Early non-motor symptoms in Huntington's disease (HD), including visual perceptual difficulties, can have profound negative impacts on quality of life. In particular, deficits in emotion recognition may contribute to misinterpretation of social cues, and may adversely affect interpersonal relationships, work relationships and/or general well-being. This may be particularly salient during the pre-manifest period, a period prior to the onset of motor symptoms. We sought to evaluate impairments in emotion recognition in gene-positive individuals who did not meet criterial for a diagnosis of HD; we also sought to determine associations between emotion recognition processing and altered cortico-striatal circuitry. We used a standardized battery to evaluate performance on a facial expression recognition task in a cohort of motor pre-manifest HD (Pre-HD) individuals (N = 21). Functional MRI (fMRI) was then used to assess the face processing network in a subset (N = 15). We found significantly decreased response accuracy to certain facial expressions, particularly of negative emotions (p 
ISSN:1353-8020
1873-5126
DOI:10.1016/j.parkreldis.2023.105289