OMA1 clears traffic jam in TOM tunnel in mammals

Using an engineered mitochondrial clogger, Krakowczyk et al. (https://doi.org/10.1083/jcb.202306051) identified the OMA1 protease as a critical component that eliminates import failure at the TOM translocase in mammalian cells, providing a novel quality control mechanism that is distinct from those...

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Veröffentlicht in:	The Journal of cell biology 2024-05, Vol.223 (5)
Hauptverfasser:	Sekine, Shiori, Sekine, Yusuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Mammals Metalloproteases - metabolism Mitochondria Mitochondrial Precursor Protein Import Complex Proteins Mitochondrial Proteins - metabolism Organelles Peptide Hydrolases Saccharomyces cerevisiae - genetics Spotlight
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Zusammenfassung:	Using an engineered mitochondrial clogger, Krakowczyk et al. (https://doi.org/10.1083/jcb.202306051) identified the OMA1 protease as a critical component that eliminates import failure at the TOM translocase in mammalian cells, providing a novel quality control mechanism that is distinct from those described in yeast.
ISSN:	0021-9525 1540-8140 1540-8140
DOI:	10.1083/jcb.202403190