Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice

The purpose of this work was to examine the effects of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting of 60% of total calories for 12 weeks. PGA-K administration reduced the increase in body weight, epididymal fat, and liver weight caused by a high-fat diet compared to the...

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Veröffentlicht in:Nutrients 2024-03, Vol.16 (6), p.809
Hauptverfasser: Lee, Seung-Hyeon, Choi, Jiwon, Park, Jae Young, Kim, Ha-Rim, Shim, Myeongkuk, Im, Kyunghyun, Choe, Hyeonjeong, Choi, Jae-Chul, Park, Young-Chul, Lim, Tae-Gyu, Seo, Hyangyim, Jang, Hansu, Oh, Boung-Jun, Kim, Seon-Young, Park, Mi Hee
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Sprache:eng
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Zusammenfassung:The purpose of this work was to examine the effects of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting of 60% of total calories for 12 weeks. PGA-K administration reduced the increase in body weight, epididymal fat, and liver weight caused by a high-fat diet compared to the obese group. The triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels, which are blood lipid indicators, were significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. The administration of PGA-K resulted in a significant inhibition of pro-inflammatory cytokines, including tumor necrosis factor α and interleukin 6. Moreover, the levels of leptin and insulin, which are insulin resistance indicators, significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. These results suggest that PGA-K exhibits a protective effect against obesity induced by a high-fat diet, underscoring its potential as a candidate for obesity treatment.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16060809