Understanding the In Vivo Fate of Advanced Materials by Imaging

Engineered materials are ubiquitous in biomedical applications ranging from systemic drug delivery systems to orthopedic implants, and their actions unfold across multiple time‐ and length‐scales. The efficacy and safety of biologics, nanomaterials, and macroscopic implants are all dictated by the s...

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Veröffentlicht in:Advanced functional materials 2020-09, Vol.30 (37), p.n/a
Hauptverfasser: Li, Ran, Ng, Thomas S. C., Garlin, Michelle A., Weissleder, Ralph, Miller, Miles A.
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Sprache:eng
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Zusammenfassung:Engineered materials are ubiquitous in biomedical applications ranging from systemic drug delivery systems to orthopedic implants, and their actions unfold across multiple time‐ and length‐scales. The efficacy and safety of biologics, nanomaterials, and macroscopic implants are all dictated by the same general principles of pharmacology as applied to small molecule drugs, comprising how the body affects materials (pharmacokinetics, PK) and conversely how materials affect the body (pharmacodynamics, PD). Imaging technologies play an increasingly insightful role in monitoring both of these processes, often simultaneously: translational macroscopic imaging modalities such as magnetic resonance imaging and positron emission tomography/computed tomography offer whole‐body quantitation of biodistribution and structural or molecular response, while ex vivo approaches and optical imaging via in vivo (intravital) microscopy reveal behaviors at subcellular resolution. In this review, the authors survey developments in imaging the in situ behavior of systemically and locally administered materials, with a particular focus on using microscopy to understand transport, target engagement, and downstream host responses at a single‐cell level. The themes of microenvironmental influence, controlled drug release, on‐target molecular action, and immune response, especially as mediated by macrophages and other myeloid cells, are examined. Finally, the future directions of how new imaging technologies may propel efficient clinical translation of next‐generation therapeutics and medical devices are proposed. The efficacy and safety of engineered materials, such as biologics, nanoparticles, and biomedical implants, are jointly dictated by their pharmacokinetic and pharmacodynamic properties in the body. In vivo imaging techniques, especially intravital microscopy, are invaluable tools to dissect the interaction of such materials with biological processes over time and in physiologically relevant contexts.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201910369