Trends of Early Helicobacter pylori -Uninfected Gastric Cancer in an Aging Regional Area

: We aimed to determine the trends over time and current status of early -uninfected gastric cancer (HpUIGC) treatment in a region with an aging population. : This retrospective, multi-center observational study was conducted at seven major general hospitals in Kagoshima Prefecture. From January 2009 to July 2022, 2091 patients who received endoscopic resection (ER) for early gastric cancer (EGC) were retrospectively enrolled, of which 35 were identified as early HpUIGC cases. : The number of ERs for EGC demonstrated a significant increasing trend from 2010 to 2021 ( = 0.01 for trend). Furthermore, the 12-year period from 2010 to 2021 was divided into an early and late phase every 6 years. In the early phase, there were 5 cases (0.7%) of early HpUIGC, while in the late phase, there were 25 cases (2.1%), indicating a significant increase in the proportion of ERs for early HpUIGC cases in the late phase ( = 0.02). : The proportion of ERs for early HpUIGC, which are more common in relatively young patients, may be increasing as a proportion of all ERs for GC, even in areas of Japan with an aging population.