Routine KIT p.D816V screening identifies clonal mast cell disease in Hymenoptera allergic patients regularly missed using baseline tryptase levels alone

Routine KIT p.D816V screening identifies clonal mast cell disease in Hymenoptera allergic patients regularly missed using baseline tryptase levels alone

Presence of the KIT p.D816V is most commonly associated with normal BST, while HαT is the most common cause of elevated BST, among individuals with severe HVA and should be considered clinically to risk-stratify patients with venom allergy.

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Veröffentlicht in:Journal of allergy and clinical immunology 2021-03, Vol.148 (2), p.621-626.e7
Hauptverfasser: Šelb, Julij, Rijavec, Matija, Eržen, Renato, Zidarn, Mihaela, Kopač, Peter, Škerget, Matevž, Bajrović, Nissera, Luzar, Ajda Demšar, Park, Young Hwan, Liu, Yihui, Šerbec, Vladka Čurin, Zver, Samo, Košnik, Mitja, Lyons, Jonathan J., Korošec, Peter
Format: Artikel
Sprache:eng
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Zusammenfassung:Presence of the KIT p.D816V is most commonly associated with normal BST, while HαT is the most common cause of elevated BST, among individuals with severe HVA and should be considered clinically to risk-stratify patients with venom allergy.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2021.02.043