TMEM65 promotes gastric tumorigenesis by targeting YWHAZ to activate PI3K-Akt-mTOR pathway and is a therapeutic target

Copy number alterations are crucial for the development of gastric cancer (GC). Here, we identified Transmembrane Protein 65 (TMEM65) amplification by genomic hybridization microarray to profile copy-number variations in GC. TMEM65 mRNA level was significantly up-regulated in GC compared to adjacent...

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Veröffentlicht in:	Oncogene 2024-03, Vol.43 (13), p.931-943
Hauptverfasser:	Shi, Lingxue, Wang, Xiaohong, Guo, Shang, Gou, Hongyan, Shang, Haiyun, Jiang, Xiaojia, Wei, Chunxian, Wang, Jia, Li, Chao, Wang, Lihong, Zhao, Zengren, Yu, Weifang, Yu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase 13 13/2 14-3-3 Proteins - metabolism 631/208/68 631/80 82 82/51 82/58 AKT protein Apoptosis Carcinogenesis - genetics Cell Biology Cell cycle Cell Line, Tumor Cell migration Cell proliferation Cell Proliferation - genetics Cell Transformation, Neoplastic Copy number Cytoplasm DNA microarrays Ectopic expression Gastric cancer Glycogen Synthase Kinase 3 beta - metabolism Human Genetics Humans Hybridization Internal Medicine Medical prognosis Medicine Medicine & Public Health Metastases mRNA Oncology Phosphatidylinositol 3-Kinases - genetics Phosphatidylinositol 3-Kinases - metabolism Proto-Oncogene Proteins c-akt - metabolism Signal transduction siRNA Stomach Neoplasms - genetics Stomach Neoplasms - pathology Therapeutic targets TOR protein TOR Serine-Threonine Kinases - genetics TOR Serine-Threonine Kinases - metabolism Transcription Factors - metabolism Tryptophan Tryptophan 5-monooxygenase Tumorigenesis Tyrosine 3-monooxygenase Ubiquitin
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Zusammenfassung:	Copy number alterations are crucial for the development of gastric cancer (GC). Here, we identified Transmembrane Protein 65 (TMEM65) amplification by genomic hybridization microarray to profile copy-number variations in GC. TMEM65 mRNA level was significantly up-regulated in GC compared to adjacent normal tissues, and was positively associated with TMEM65 amplification. High TMEM65 expression or DNA copy number predicts poor prognosis ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/s41388-024-02959-9