Adverse Pregnancy Outcomes Among Women with Human Immunodeficiency Virus Taking Isoniazid Preventive Therapy During the First Trimester

Adverse Pregnancy Outcomes Among Women with Human Immunodeficiency Virus Taking Isoniazid Preventive Therapy During the First Trimester

Abstract Background Isoniazid preventive therapy (IPT) is recommended for tuberculosis prevention yet data on the safety of first-trimester pregnancy exposure are limited. Methods Planned secondary analysis in a TB prevention trial of adverse pregnancy outcomes among participants assigned to 9-month...

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Veröffentlicht in:Clinical infectious diseases 2024-03, Vol.78 (3), p.667-673
Hauptverfasser: Gupta, Amita, Hughes, Michael D, Cruz, Jorge Leon, Avihingsanon, Anchalee, Mwelase, Noluthando, Severe, Patrice, Omoz-Oarhe, Ayotunde, Masheto, Gaerolwe, Moran, Laura, Benson, Constance A, Chaisson, Richard E, Swindells, Susan
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Sprache:eng
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Zusammenfassung:Abstract Background Isoniazid preventive therapy (IPT) is recommended for tuberculosis prevention yet data on the safety of first-trimester pregnancy exposure are limited. Methods Planned secondary analysis in a TB prevention trial of adverse pregnancy outcomes among participants assigned to 9-month IPT who became pregnant during (IPT-exposed) or after (unexposed) IPT. Regression models compared binary outcomes of a composite adverse outcome (any non-live birth, excluding induced abortion); preterm delivery
ISSN:1058-4838
1537-6591
1537-6591
DOI:10.1093/cid/ciad583