Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM‐7)

Acetaminophen Metabolites on Presentation Following an Acute Acetaminophen Overdose (ATOM‐7)

Acetaminophen (APAP) is commonly taken in overdose and can cause acute liver injury via the toxic metabolite NAPQI formed by cytochrome (CYP) P450 pathway. We aimed to evaluate the concentrations of APAP metabolites on presentation following an acute APAP poisoning and whether these predicted the su...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Clinical pharmacology and therapeutics 2023-06, Vol.113 (6), p.1304-1314
Hauptverfasser: Chiew, Angela L., Isbister, Geoffrey K., Stathakis, Paul, Isoardi, Katherine Z., Page, Colin, Ress, Kirsty, Chan, Betty S.H., Buckley, Nicholas A.
Format: Artikel
Sprache:eng
Schlagworte:
Acetaminophen - therapeutic use
Acetylcysteine
Analgesics, Non-Narcotic - therapeutic use
Australia
Chemical and Drug Induced Liver Injury - diagnosis
Chemical and Drug Induced Liver Injury - etiology
Drug Overdose - drug therapy
Humans
Liver
Retrospective Studies
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Acetaminophen (APAP) is commonly taken in overdose and can cause acute liver injury via the toxic metabolite NAPQI formed by cytochrome (CYP) P450 pathway. We aimed to evaluate the concentrations of APAP metabolites on presentation following an acute APAP poisoning and whether these predicted the subsequent onset of hepatotoxicity (peak alanine aminotransferase > 1,000 U/L). The Australian Toxicology Monitoring (ATOM) study is a prospective observational study, recruiting via two poison information centers and four toxicology units. Patients following an acute APAP ingestion presenting
ISSN:0009-9236
1532-6535
DOI:10.1002/cpt.2888