Cryopreservation of mouse thymus depletes thymocytes but supports immune reconstitution on transplantation
Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outc...
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Veröffentlicht in: | European journal of immunology 2023-12, Vol.53 (12), p.e2350546-n/a |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Cryopreservation of mouse thymus depletes donor thymocytes but preserves thymus function when transplanted after thawing into athymic mice. No differences in immune reconstitution were observed between fresh and frozen/thawed transplants suggesting that donor thymocyte depletion does not affect outcome. Thus, cryopreservation of thymus may improve outcomes in thymus transplant patients. |
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ISSN: | 0014-2980 1521-4141 |
DOI: | 10.1002/eji.202350546 |