Risk of COVID‐19 Hospitalization and Protection Associated With mRNA Vaccination Among US Adults With Psychiatric Disorders

ABSTRACT Background Although psychiatric disorders have been associated with reduced immune responses to other vaccines, it remains unknown whether they influence COVID‐19 vaccine effectiveness (VE). This study evaluated risk of COVID‐19 hospitalization and estimated mRNA VE stratified by psychiatri...

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Veröffentlicht in:	Influenza and other respiratory viruses 2024-03, Vol.18 (3), p.e13269-n/a
Hauptverfasser:	Levy, Matthew E., Yang, Duck‐Hye, Dunne, Margaret M., Miley, Kathleen, Irving, Stephanie A., Grannis, Shaun J., Weber, Zachary A., Griggs, Eric P., Spark, Talia L., Bassett, Elizabeth, Embi, Peter J., Gaglani, Manjusha, Natarajan, Karthik, Valvi, Nimish R., Ong, Toan C., Naleway, Allison L., Stenehjem, Edward, Klein, Nicola P., Link‐Gelles, Ruth, DeSilva, Malini B., Kharbanda, Anupam B., Raiyani, Chandni, Beaton, Maura A., Dixon, Brian E., Rao, Suchitra, Dascomb, Kristin, Patel, Palak, Mamawala, Mufaddal, Han, Jungmi, Fadel, William F., Barron, Michelle A., Grisel, Nancy, Dickerson, Monica, Liao, I‐Chia, Arndorfer, Julie, Najdowski, Morgan, Murthy, Kempapura, Ray, Caitlin, Tenforde, Mark W., Ball, Sarah W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Adults Age groups anxiety disorders Clinical outcomes Codes Cohort analysis COVID-19 COVID-19 - epidemiology COVID-19 - prevention & control COVID-19 Vaccines Disorders Drug dosages Electronic health records epidemiology FDA approval Health behavior Health disparities Health risks Hospitalization Humans Immune response Infections Inpatient care Intervention Mental disorders Mental Disorders - epidemiology mood disorders mRNA mRNA vaccines Original Psychosis psychotic disorders Public health Retrospective Studies Risk RNA, Messenger Severe acute respiratory syndrome coronavirus 2 Vaccination Vaccine efficacy Vaccines
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Zusammenfassung:	ABSTRACT Background Although psychiatric disorders have been associated with reduced immune responses to other vaccines, it remains unknown whether they influence COVID‐19 vaccine effectiveness (VE). This study evaluated risk of COVID‐19 hospitalization and estimated mRNA VE stratified by psychiatric disorder status. Methods In a retrospective cohort analysis of the VISION Network in four US states, the rate of laboratory‐confirmed COVID‐19‐associated hospitalization between December 2021 and August 2022 was compared across psychiatric diagnoses and by monovalent mRNA COVID‐19 vaccination status using Cox proportional hazards regression. Results Among 2,436,999 adults, 22.1% had ≥1 psychiatric disorder. The incidence of COVID‐19‐associated hospitalization was higher among patients with any versus no psychiatric disorder (394 vs. 156 per 100,000 person‐years, p
ISSN:	1750-2640 1750-2659
DOI:	10.1111/irv.13269