Risk of supranormal left ventricular ejection fraction in patients with aortic stenosis

Background Cardiovascular events are increasing in patients with supranormal left ventricular ejection fraction (snLVEF). However, the effect of snLVEF in patients with aortic stenosis (AS) remains unclear, especially in patients with moderate AS. Hypothesis This study aimed to evaluate the prognosis of mortality and heart failure (HF) in patients with LVEF ≥ 50% and moderate or severe AS. Methods This retrospective study targeted patients with moderate or severe AS and LVEF > 50%. LVEF of 50%–65% was classified as normal LVEF (nLVEF, nEF group) and >65% as snLVEF (snEF group). AS severity was stratified based on the aortic valve area into moderate (1.0–1.5 cm²) and severe ( 65%) may increase the risk of heart failure hospitalization. The risk did not differ significantly between moderate AS + supranormal LVEF and severe AS + normal LVEF cases.