Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse

Synapses with high release probability ( ) tend to exhibit short-term synaptic depression. According to the prevailing model, this reflects the temporary depletion of release-ready vesicles after an initial action potential (AP). At the high- layer 4 to layer 2/3 (L4-L2/3) synapse in rodent somatose...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of neuroscience 2024-02, Vol.44 (9), p.e1756232023
Hauptverfasser:	Chiu, Delia N, Carter, Brett C
Format:	Artikel
Sprache:	eng
Schlagworte:	Action potential Animals Calcium Calcium - metabolism Calcium imaging Cortex (somatosensory) Depletion Desensitization Electrophysiology Female Male Mice Neuroimaging Neuromodulation Neuronal Plasticity - physiology Neurotransmission Plastic properties Plasticity Synapses Synapses - physiology Synaptic depression Synaptic Transmission - physiology Synaptotagmin Synaptotagmins - genetics Synaptotagmins - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Synapses with high release probability ( ) tend to exhibit short-term synaptic depression. According to the prevailing model, this reflects the temporary depletion of release-ready vesicles after an initial action potential (AP). At the high- layer 4 to layer 2/3 (L4-L2/3) synapse in rodent somatosensory cortex, short-term plasticity appears to contradict the depletion model: depression is absent at interstimulus intervals (ISIs)
ISSN:	0270-6474 1529-2401 1529-2401
DOI:	10.1523/JNEUROSCI.1756-23.2023