Monocyte transcriptomic profile following EPA and DHA supplementation in men and women with low-grade chronic inflammation

Recent data indicate considerable variability in response to very long chain omega-3 fatty acid supplementation on cardiovascular disease risk. This inconsistency may be due to differential effects of EPA vs DHA and/or sex-specific responses. Sixteen subjects (eight men and eight women) 50–75 y and...

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Veröffentlicht in:	Atherosclerosis 2024-01, Vol.388, p.117407-117407, Article 117407
Hauptverfasser:	So, Jisun, Wu, Dayong, Tai, Albert K., Lichtenstein, Alice H., Matthan, Nirupa R., Lamon-Fava, Stefania
Format:	Artikel
Sprache:	eng
Schlagworte:	Dietary Supplements Docosahexaenoic Acids Double-Blind Method Eicosapentaenoic Acid - therapeutic use Fatty Acids, Omega-3 Female Gene Expression Profiling Humans Inflammation Macrophages Male Monocytes Omega-3 fatty acids Specialized pro-resolving lipid mediators Transcriptome Transcriptomics
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Zusammenfassung:	Recent data indicate considerable variability in response to very long chain omega-3 fatty acid supplementation on cardiovascular disease risk. This inconsistency may be due to differential effects of EPA vs DHA and/or sex-specific responses. Sixteen subjects (eight men and eight women) 50–75 y and with low-grade chronic inflammation participated in a randomized controlled crossover trial comparing 3 g/d EPA, 3 g/d DHA, and placebo (3 g/d high oleic acid sunflower oil). Blood monocytes were isolated at the end of each phase for RNA-sequencing. Sex dimorphism in monocyte gene expression was observed, therefore, data for men and women were analyzed separately. 1088 genes were differentially expressed in men and 997 in women (p
ISSN:	0021-9150 1879-1484 1879-1484
DOI:	10.1016/j.atherosclerosis.2023.117407