C/EBP homogenous protein-induced Apoptosis in Endoplasmic Reticulum stress has been implicated in Kikuchi–Fujimoto Disease

[TO THE EDITOR] Kikuchi-Fujimoto disease (KFD), a systemic reactive disease with characteristic clinical manifestations including high fever, painful cervical lymphadenopathy, and leukopenia, is not seasonal. The disease is known to be antibiotic resistant, to have elevated 2'-5' oligoadenylic acid synthesizing enzyme, to have exhibited transient elevations in viral antibody titer in a few cases, and to induce Mx1 protein without granulocytes in lymph node lesions. Histologically and immunohistochemically, CD8+ T cells become larger by blastic transformation without apoptosis, and CD4+ T cells undergo apoptosis and are subsequently phagocytized by macrophages.