Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents
In the present study, some 9-aminoacridine derivatives have been synthesized by condensation of 9-aminoacridine with substituted phenacyl, benzoyl, and benzyl halides (RM1-RM6). Compounds were investigated for acetylcholinesterase and butyrylcholinesterase inhibition potential, considering these enz...
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| Veröffentlicht in: | American journal of Alzheimer's disease and other dementias 2016-05, Vol.31 (3), p.263-269 |
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| container_end_page | 269 |
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| container_issue | 3 |
| container_start_page | 263 |
| container_title | American journal of Alzheimer's disease and other dementias |
| container_volume | 31 |
| creator | Munawar, Rabya Mushtaq, Nousheen Arif, Sadia Ahmed, Ahsaan Akhtar, Shamim Ansari, Sumaira Meer, Sadia Saify, Zafar S. Arif, Muhammad |
| description | In the present study, some 9-aminoacridine derivatives have been synthesized by condensation of 9-aminoacridine with substituted phenacyl, benzoyl, and benzyl halides (RM1-RM6). Compounds were investigated for acetylcholinesterase and butyrylcholinesterase inhibition potential, considering these enzymes playing a key role in Alzheimer’s disease. All derivatives showed better inhibition of enzymes than the standard galantamine, whereas except RM4, all exhibit better results than tacrine, a well-known acridine derivative used for the treatment of Alzheimer’s disease. |
| doi_str_mv | 10.1177/1533317515603115 |
| format | Article |
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Compounds were investigated for acetylcholinesterase and butyrylcholinesterase inhibition potential, considering these enzymes playing a key role in Alzheimer’s disease. 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| identifier | ISSN: 1533-3175 |
| ispartof | American journal of Alzheimer's disease and other dementias, 2016-05, Vol.31 (3), p.263-269 |
| issn | 1533-3175 1938-2731 |
| language | eng |
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| source | SAGE Journals |
| subjects | Alzheimer Disease - drug therapy Alzheimer Disease - enzymology Aminacrine - chemical synthesis Cholinesterase Inhibitors - chemical synthesis Current Topics in Research Humans In Vitro Techniques |
| title | Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents |
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