Synthesis of 9-Aminoacridine Derivatives as Anti-Alzheimer Agents

In the present study, some 9-aminoacridine derivatives have been synthesized by condensation of 9-aminoacridine with substituted phenacyl, benzoyl, and benzyl halides (RM1-RM6). Compounds were investigated for acetylcholinesterase and butyrylcholinesterase inhibition potential, considering these enz...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:American journal of Alzheimer's disease and other dementias 2016-05, Vol.31 (3), p.263-269
Hauptverfasser: Munawar, Rabya, Mushtaq, Nousheen, Arif, Sadia, Ahmed, Ahsaan, Akhtar, Shamim, Ansari, Sumaira, Meer, Sadia, Saify, Zafar S., Arif, Muhammad
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:In the present study, some 9-aminoacridine derivatives have been synthesized by condensation of 9-aminoacridine with substituted phenacyl, benzoyl, and benzyl halides (RM1-RM6). Compounds were investigated for acetylcholinesterase and butyrylcholinesterase inhibition potential, considering these enzymes playing a key role in Alzheimer’s disease. All derivatives showed better inhibition of enzymes than the standard galantamine, whereas except RM4, all exhibit better results than tacrine, a well-known acridine derivative used for the treatment of Alzheimer’s disease.
ISSN:1533-3175
1938-2731
DOI:10.1177/1533317515603115