Thiamine administration in septic shock: a post hoc analysis of two randomized trials

Thiamine administration in septic shock: a post hoc analysis of two randomized trials

This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock. Patient-level data from the Thiamine in Septic Shock Trial (NCT01070810) and the Thiamine for R...

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Veröffentlicht in:Critical care (London, England) England), 2024-02, Vol.28 (1), p.41, Article 41
Hauptverfasser: Vine, Jacob, Lee, John H, Kravitz, Max S, Grossestreuer, Anne V, Balaji, Lakshman, Leland, Shannon B, Berlin, Noa, Moskowitz, Ari, Donnino, Michael W
Format: Artikel
Sprache:eng
Schlagworte:
Brief Report
Complications and side effects
Creatinine
Dosage and administration
Drug therapy
Enrollments
Humans
Kidney
Kidney diseases
Kidneys
Mortality
Patient outcomes
Patients
Prevention
Randomized Controlled Trials as Topic
Regression analysis
Risk factors
Sensitivity analysis
Sepsis
Sepsis - complications
Septic shock
Shock, Septic - drug therapy
Thiamine - therapeutic use
Thiamine Deficiency - complications
Thiamine Deficiency - drug therapy
Variables
Vitamin B
Vitamin B1
Vitamin deficiency
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Beschreibung
Zusammenfassung:This is a post hoc analysis of combined cohorts from two previous Phase II clinical trials to assess the effect of thiamine administration on kidney protection and mortality in patients with septic shock. Patient-level data from the Thiamine in Septic Shock Trial (NCT01070810) and the Thiamine for Renal Protection in Septic Shock Trial (NCT03550794) were combined in this analysis. The primary outcome for the current study was survival without the receipt of renal replacement therapy (RRT). Analyses were performed on the overall cohort and the thiamine-deficient cohort (thiamine 
ISSN:1364-8535
1466-609X
1466-609X
1364-8535
1366-609X
DOI:10.1186/s13054-024-04818-1