Pd-Catalyzed [4 + 1] Annulation Strategy to Functionalized 4‑Methyleneproline Derivatives

Pd-Catalyzed [4 + 1] Annulation Strategy to Functionalized 4‑Methyleneproline Derivatives

A Pd-catalyzed formal [4 + 1] cycloaddition reaction of sulfur ylides and in situ-generated Pd-stabilized zwitterions offers a convenient route to a series of functionalized proline derivatives. The utility of this method is demonstrated by a gram-scale synthesis and chemoselective functionalization...

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Veröffentlicht in:Journal of organic chemistry 2024-02, Vol.89 (3), p.1552-1555
Hauptverfasser: Han, Jiaxin, Gao, Wenzheng, Harrity, Joseph P. A.
Format: Artikel
Sprache:eng
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Zusammenfassung:A Pd-catalyzed formal [4 + 1] cycloaddition reaction of sulfur ylides and in situ-generated Pd-stabilized zwitterions offers a convenient route to a series of functionalized proline derivatives. The utility of this method is demonstrated by a gram-scale synthesis and chemoselective functionalization of a proline-based derivative.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.3c02178