Nasal epithelial gene expression and total IgE in children and adolescents with asthma

Nasal epithelial gene expression and total IgE in children and adolescents with asthma

Little is known about nasal epithelial gene expression and total IgE in youth. We conducted a transcriptome-wide association study (TWAS) of total IgE in 469 Puerto Ricans aged 9-20 years who participated in the Epigenetic Variation and Childhood Asthma in Puerto Rico (EVA-PR) study, separately in a...

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Veröffentlicht in:Journal of allergy and clinical immunology 2024-01, Vol.153 (1), p.122-131
Hauptverfasser: Xu, Zhongli, Forno, Erick, Sun, Yidan, Manni, Michelle, Han, Yueh Ying, Kim, Soyeon, Yue, Molin, Vonk, Judith M., Kersten, Elin T.M., Acosta-Perez, Edna, Canino, Glorisa, Koppelman, Gerard H., Chen, Wei, Celedón, Juan C.
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Asthma
Child
childhood asthma
EVA-PR
Humans
Immunoglobulin E
Interleukin-13 - genetics
Nose
total IgE
Transcriptome
TWAS
VDKA
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Zusammenfassung:Little is known about nasal epithelial gene expression and total IgE in youth. We conducted a transcriptome-wide association study (TWAS) of total IgE in 469 Puerto Ricans aged 9-20 years who participated in the Epigenetic Variation and Childhood Asthma in Puerto Rico (EVA-PR) study, separately in all subjects and in those with asthma. We then attempted to replicate top findings for each analysis using data from three cohorts. Genes with Benjamini-Hochberg (BH)-adjusted P
ISSN:0091-6749
1097-6825
1097-6825
DOI:10.1016/j.jaci.2023.09.014