Extracellular release of antigenic proteins by Helicobacter pylori

Screening a Helicobacter pylori genomic library with antisera raised against H. pylori broth culture supernatant resulted in the identification of six antigens: urease, HspB, Lpp20, DnaK, MsrA, and a cysteine-rich 28-kDa protein (designated HcpA). H. pylori antigens may be released into the extracel...

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Veröffentlicht in:	Infection and immunity 1998-06, Vol.66 (6), p.2984-2986
Hauptverfasser:	PING CAO, MCCLAIN, M. S, FORSYTH, M. H, COVER, T. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antigens, Bacterial - genetics Antigens, Bacterial - metabolism Bacterial Proteins - genetics Bacterial Proteins - metabolism Bacteriology Biological and medical sciences Escherichia coli Proteins Fundamental and applied biological sciences. Psychology Genomic Library Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism Helicobacter pylori - genetics Helicobacter pylori - immunology Helicobacter pylori - metabolism Hemolysin Proteins HSP70 Heat-Shock Proteins - genetics HSP70 Heat-Shock Proteins - metabolism Lipoproteins - genetics Lipoproteins - metabolism Membrane Transport Proteins Microbiology Molecular and Cellular Pathogenesis Molecular Sequence Data Permeability, membrane transport, intracellular transport Plasmids - genetics Sequence Analysis, DNA Sequence Homology, Amino Acid
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Beschreibung
Zusammenfassung:	Screening a Helicobacter pylori genomic library with antisera raised against H. pylori broth culture supernatant resulted in the identification of six antigens: urease, HspB, Lpp20, DnaK, MsrA, and a cysteine-rich 28-kDa protein (designated HcpA). H. pylori antigens may be released into the extracellular space by multiple mechanisms, including specific secretion pathways, autolysis, and membrane vesicle formation.
ISSN:	0019-9567 1098-5522
DOI:	10.1128/iai.66.6.2984-2986.1998