IκB kinase thwarts aggregation: Phosphorylating TDP-43 for degradation

IκB kinase thwarts aggregation: Phosphorylating TDP-43 for degradation

TDP-43 aggregation is a hallmark of neurodegeneration. In this issue, Iguchi et al. (https://doi.org/10.1083/jcb.202302048) report that IκB kinase (IKK), an important mediator of inflammation, phosphorylates cytoplasmic TDP-43 to promote proteasomal degradation, revealing an unexpected link between...

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Veröffentlicht in:The Journal of cell biology 2024-02, Vol.223 (2), p.1
Hauptverfasser: Yang, Cha, Liu, Yanru, Hu, Fenghua
Format: Artikel
Sprache:eng
Schlagworte:
Biochemistry
Cytoplasm
Cytosol
DNA-Binding Proteins - genetics
Humans
I-kappa B Kinase
Inflammation
Kinases
Neuroscience
Protein Homeostasis
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Zusammenfassung:TDP-43 aggregation is a hallmark of neurodegeneration. In this issue, Iguchi et al. (https://doi.org/10.1083/jcb.202302048) report that IκB kinase (IKK), an important mediator of inflammation, phosphorylates cytoplasmic TDP-43 to promote proteasomal degradation, revealing an unexpected link between inflammation and TDP-43 homeostasis.
ISSN:0021-9525
1540-8140
1540-8140
DOI:10.1083/jcb.202311176