On the causal role of retromer-dependent endosomal recycling in Alzheimer’s disease

On the causal role of retromer-dependent endosomal recycling in Alzheimer’s disease

Recent findings ranging from genetics to structural biology, together with studies in human neurons, animal models and patient brains, implicate the retromer-dependent endosomal recycling pathway as both causal and common in Alzheimer’s disease.

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Veröffentlicht in:Nature cell biology 2023-10, Vol.25 (10), p.1394-1397
Hauptverfasser: Young, Jessica E., Holstege, Henne, Andersen, Olav M., Petsko, Gregory A., Small, Scott A.
Format: Artikel
Sprache:eng
Schlagworte:
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Alzheimer Disease
Alzheimer's disease
Animal models
Biomedical and Life Sciences
Cancer Research
Cell Biology
Comment
Developmental Biology
Endosomes - metabolism
Gene expression
Genetics
Humans
Life Sciences
Molecular biology
Morphology
Neurodegenerative diseases
Pathology
Protein Transport
Proteins
Recycling
Stem Cells
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Beschreibung
Zusammenfassung:Recent findings ranging from genetics to structural biology, together with studies in human neurons, animal models and patient brains, implicate the retromer-dependent endosomal recycling pathway as both causal and common in Alzheimer’s disease.
ISSN:1465-7392
1476-4679
DOI:10.1038/s41556-023-01245-2